M
Marietta Tóth
Researcher at University of Debrecen
Publications - 39
Citations - 987
Marietta Tóth is an academic researcher from University of Debrecen. The author has contributed to research in topics: Glycogen phosphorylase & Chemistry. The author has an hindex of 15, co-authored 33 publications receiving 874 citations.
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Journal ArticleDOI
C-Glycopyranosyl Arenes and Hetarenes: Synthetic Methods and Bioactivity Focused on Antidiabetic Potential
Éva Bokor,Sándor Kun,David Goyard,Marietta Tóth,Jean-Pierre Praly,Sébastien Vidal,László Somsák +6 more
TL;DR: This Review summarizes close to 500 primary publications and surveys published since 2000 about the syntheses and diverse bioactivities of C-glycopyranosyl (het)arenes displaying among others antioxidant, antiviral, antibiotic, antiadhesive, cytotoxic, and glycoenzyme inhibitory effects.
Journal ArticleDOI
Synthesis of and a Comparative Study on the Inhibition of Muscle and Liver Glycogen Phosphorylases by Epimeric Pairs of d-Gluco- and d-Xylopyranosylidene-spiro-(thio)hydantoins and N-(d-Glucopyranosyl) Amides
László Somsák,Laszlo Kovacs,Marietta Tóth,Erzsebet Osz,László Szilágyi,Zoltán Györgydeák,Zoltán Dinya,Tibor Docsa,Béla Tóth,Pál Gergely +9 more
TL;DR: The study of epimeric pairs of D-gluco and D-xylo configurated spiro-hydantoins and N-(D-glucopyranosyl)amides corroborated the role of specific hydrogen bridges in binding the inhibitors to the enzyme.
Journal ArticleDOI
New Inhibitors of Glycogen Phosphorylase as Potential Antidiabetic Agents
László Somsák,Katalin Czifrák,Marietta Tóth,Éva Bokor,Evangelia D. Chrysina,K.-M. Alexacou,Joseph Hayes,C. Tiraidis,E. Lazoura,Demetres D. Leonidas,Spyros E. Zographos,Nikos G. Oikonomakos +11 more
TL;DR: The synthesis, structure determination and computational studies of the most recent inhibitors of glycogen phosphorylase at the different binding sites are presented and analyzed and have the potential to facilitate structure-based drug design.
Journal ArticleDOI
Synthesis and structure-activity relationships of C-glycosylated oxadiazoles as inhibitors of glycogen phosphorylase
Marietta Tóth,Sándor Kun,Éva Bokor,Mahmoud Benltifa,Gaylord Tallec,Sébastien Vidal,Tibor Docsa,Pál Gergely,László Somsák,Jean Pierre Praly +9 more
TL;DR: The 5-beta-D-glucopyranosyl-3-(4-methylphenyl- and -2-naphthyl)-1,2,4-oxadiazoles were practically inefficient as inhibitors of rabbit muscle glycogen phosphorylase b while the 2,6-anhydro-aldose benzoylhydrazones displayed inhibitory activities in the micromolar range.
Journal ArticleDOI
Synthesis of N-(β-D-glucopyranosyl)- and N-(2-acetamido-2-deoxy-β-D-glucopyranosyl) amides as inhibitors of glycogen phosphorylase
Zoltán Györgydeák,Zsuzsa Hadady,Nóra Felföldi,Attila Krakomperger,Veronika Nagy,Marietta Tóth,Attila Brunyanszki,Tibor Docsa,Pál Gergely,László Somsák +9 more
TL;DR: In this article, the deprotected compounds obtained by Zemplen deacetylation were evaluated as inhibitors of rabbit muscle glycogen phosphorylase b. The best inhibitor has been N -(β- D -glucopyranosyl) 3-(2-naphthyl)-propenoic amide (K i ǫ = 3.5μM).