M
Marianela Candolfi
Researcher at University of Buenos Aires
Publications - 89
Citations - 3691
Marianela Candolfi is an academic researcher from University of Buenos Aires. The author has contributed to research in topics: Glioma & Immunotherapy. The author has an hindex of 34, co-authored 85 publications receiving 3268 citations. Previous affiliations of Marianela Candolfi include University of California, Los Angeles & University of California.
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Journal ArticleDOI
HMGB1 Mediates Endogenous TLR2 Activation and Brain Tumor Regression
James F. Curtin,James F. Curtin,Naiyou Liu,Naiyou Liu,Marianela Candolfi,Marianela Candolfi,Weidong Xiong,Weidong Xiong,Hikmat Assi,Hikmat Assi,Kader Yagiz,Kader Yagiz,Matthew R. Edwards,Kathrin S. Michelsen,Kurt M. Kroeger,Kurt M. Kroeger,Chunyan Liu,Chunyan Liu,A.K.M. Ghulam Muhammad,A.K.M. Ghulam Muhammad,Mary C. Clark,Mary C. Clark,Moshe Arditi,Begonya Comin-Anduix,Antoni Ribas,Pedro R. Lowenstein,Maria G. Castro +26 more
TL;DR: Evidence is provided for the molecular and cellular mechanisms that support the rationale for the clinical implementation of antibrain cancer immunotherapies in combination with tumor killing approaches in order to elicit effective antitumor immune responses, and thus, will impact clinical neuro-oncology practice.
Journal ArticleDOI
Intracranial glioblastoma models in preclinical neuro-oncology: neuropathological characterization and tumor progression
Marianela Candolfi,Marianela Candolfi,James F. Curtin,James F. Curtin,W. Stephen Nichols,Akm Ghulam Muhammad,Gwendalyn D. King,Gwendalyn D. King,G. Elizabeth Pluhar,Elizabeth A. McNiel,John R. Ohlfest,Andrew Freese,Peter F Moore,Jonathan Lerner,Jonathan Lerner,Pedro R. Lowenstein,Pedro R. Lowenstein,Maria G. Castro,Maria G. Castro +18 more
TL;DR: The data indicate that murine models of GBM appear to recapitulate several of the human GBM histopathological features and, considering their reproducibility and availability, they constitute a valuable in vivo system for preclinical studies.
Journal ArticleDOI
Regulatable Gene Expression Systems for Gene Therapy Applications: Progress and Future Challenges
Shyam Goverdhana,Mariana Puntel,Weidong Xiong,Jeffrey M. Zirger,Carlos Barcia,James F. Curtin,E. B. Soffer,Sonali Mondkar,Gwendalyn D. King,Jiang Hu,Sandra A. Sciascia,Marianela Candolfi,Diana S. Greengold,Pedro R. Lowenstein,Maria G. Castro +14 more
TL;DR: The main regulatable systems currently under development, the gene transfer systems employed for their expression, and also the preclinical models in which they have been used successfully are highlighted and the substantial challenges that still remain are discussed.
Journal ArticleDOI
Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model
Sumia Ali,Gwendalyn D. King,James F. Curtin,Marianela Candolfi,Weidong Xiong,Chunyan Liu,Mariana Puntel,Queng Cheng,Jesús Prieto,Antoni Ribas,Jerzy W. Kupiec-Weglinski,Nico van Rooijen,Hans Lassmann,Pedro R. Lowenstein,Pedro R. Lowenstein,Maria G. Castro,Maria G. Castro +16 more
TL;DR: It is proposed that combined Flt3L and HSV1-TK adenoviral-mediated gene therapy may provide an effective antiglioma treatment with increased efficacy in clinical trials of glioma.
Journal ArticleDOI
Gene Therapy and Targeted Toxins for Glioma
Maria G. Castro,Marianela Candolfi,Kurt M. Kroeger,Gwendalyn D. King,James F. Curtin,Kader Yagiz,Yohei Mineharu,Hikmat Assi,Mia Wibowo,A.K.M. Ghulam Muhammad,David Foulad,Mariana Puntel,Pedro R. Lowenstein +12 more
TL;DR: This review will examine the available preclinical models for glioma including xenographs, syngeneic and genetic models to determine which strategies will provide rapid tumor regression and long-term protection from recurrence.