Maija Lahtela-Kakkonen

TL;DR: Withaferin A (WA) is identified as a natural ferroptosis-inducing agent in neuroblastoma, which acts through a novel double-edged mechanism that might explain the superior efficacy of WA as compared with etoposide or cisplatin in killing a heterogeneous panel of high-risk Neuroblastoma cells, and in suppressing the growth and relapse rate of neuroblastomas xenografts.

TL;DR: The role, mechanism of action, and biological function of the seven sirtuins, as well as their inhibitors and activators are reviewed.

TL;DR: A direct interaction of WA with the IKK-complex, more specifically with IKKβ, a kinase which is indispensable for the nuclear translocation of NF-κB, is demonstrated, indicating that WA exerts its anti-inflammatory effects by targeting the crucial Cys179 residue located in the catalytic site of IKK β.

TL;DR: The synthesized compounds show high selectivity toward Sirt2 over SIRT1 and SIRT3 and represent an important starting point for the development of novel SIRT2 inhibitors.

TL;DR: It is shown, that flavonoids can alter SIRT6 activity in a structure dependent manner and inhibitors and activators likely bind in a manner that could disturb NAD+ binding.