F
Feng Qu
Researcher at Peking Union Medical College
Publications - 23
Citations - 4145
Feng Qu is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 15, co-authored 20 publications receiving 2168 citations. Previous affiliations of Feng Qu include Peking University & University of Pittsburgh.
Papers
More filters
Journal ArticleDOI
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
Sebastian Doll,Bettina Proneth,Yulia Y. Tyurina,Elena Panzilius,Sho Kobayashi,Irina Ingold,Martin Irmler,Johannes Beckers,Michaela Aichler,Axel Walch,Holger Prokisch,Dietrich Trümbach,Gaowei Mao,Feng Qu,Hülya Bayır,Joachim Füllekrug,Christina Scheel,Wolfgang Wurst,Joel A. Schick,Valerian E. Kagan,José Pedro Friedmann Angeli,Marcus Conrad +21 more
TL;DR: Pharmacological targeting of ACSL4 with thiazolidinediones, a class of antidiabetic compound, ameliorated tissue demise in a mouse model of ferroptosis, suggesting that ACSL 4 inhibition is a viable therapeutic approach to preventing ferroPTosis-related diseases.
Journal ArticleDOI
Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis
Valerian E. Kagan,Gaowei Mao,Feng Qu,José Pedro Friedmann Angeli,Sebastian Doll,Claudette M. St. Croix,Haider H. Dar,Bing Liu,Vladimir A. Tyurin,Vladimir B. Ritov,Alexandr A. Kapralov,Andrew A. Amoscato,Jianfei Jiang,Tamil S. Anthonymuthu,Dariush Mohammadyani,Qin Yang,Bettina Proneth,Judith Klein-Seetharaman,Simon C. Watkins,Ivet Bahar,Joel S. Greenberger,Rama K. Mallampalli,Brent R. Stockwell,Yulia Y. Tyurina,Marcus Conrad,Hülya Bayır +25 more
TL;DR: It is discovered that ferroptosis involves a highly organized oxygenation center, wherein oxidation in endoplasmic-reticulum-associated compartments occurs on only one class of phospholipids (phosphatidylethanolamines (PEs) and is specific toward two fatty acyls-arachidonoyl (AA) and AdA (AdA).
Journal ArticleDOI
PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals
Sally E. Wenzel,Yulia Y. Tyurina,Jinming Zhao,Claudette M. St. Croix,Haider H. Dar,Gaowei Mao,Vladimir A. Tyurin,Tamil S. Anthonymuthu,Alexandr A. Kapralov,Andrew A. Amoscato,Karolina Mikulska-Ruminska,Karolina Mikulska-Ruminska,Indira H. Shrivastava,Elizabeth M. Kenny,Qin Yang,Joel C. Rosenbaum,Louis J. Sparvero,David R. Emlet,Xiaoyan Wen,Yoshinori Minami,Feng Qu,Simon C. Watkins,Theodore R. Holman,Andrew P. VanDemark,John A. Kellum,Ivet Bahar,Hülya Bayır,Hülya Bayır,Valerian E. Kagan +28 more
TL;DR: It is discovered that PEBP1, a scaffold protein inhibitor of protein kinase cascades, complexes with two 15LO isoforms, 15LO1 and 15LO2, and changes their substrate competence to generate hydroperoxy-PE, a new target for drug discovery.
Journal ArticleDOI
Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma
Behrouz Hassannia,Bartosz Wiernicki,Irina Ingold,Feng Qu,Simon Van Herck,Yulia Y. Tyurina,Hülya Bayır,Behnaz Ahangarian Abhari,José Pedro Friedmann Angeli,Sze Men Choi,Eline Meul,Karen Heyninck,Ken Declerck,Chandra Sekhar Chirumamilla,Maija Lahtela-Kakkonen,Guy Van Camp,Dmitri V. Krysko,Paul G Ekert,Simone Fulda,Simone Fulda,Bruno G. De Geest,Marcus Conrad,Valerian E. Kagan,Wim Vanden Berghe,Wim Vanden Berghe,Peter Vandenabeele,Tom Vanden Berghe +26 more
TL;DR: Withaferin A (WA) is identified as a natural ferroptosis-inducing agent in neuroblastoma, which acts through a novel double-edged mechanism that might explain the superior efficacy of WA as compared with etoposide or cisplatin in killing a heterogeneous panel of high-risk Neuroblastoma cells, and in suppressing the growth and relapse rate of neuroblastomas xenografts.
Journal ArticleDOI
Known unknowns of cardiolipin signaling : the best is yet to come
John J. Maguire,Yulia Y. Tyurina,Dariush Mohammadyani,Aleksandr A. Kapralov,Tamil S. Anthonymuthu,Feng Qu,Andrew A. Amoscato,Louis J. Sparvero,Vladimir A. Tyurin,Joan Planas-Iglesias,Rong-Rong He,Judith Klein-Seetharaman,Hülya Bayır,Valerian E. Kagan +13 more
TL;DR: The messaging functions of myriads of cardiolipin species and their oxidation products are now being recognized as important intracellular and extracellular signals for innate and adaptive immune systems.