M
Maja Aleksic
Researcher at University of Bedfordshire
Publications - 21
Citations - 615
Maja Aleksic is an academic researcher from University of Bedfordshire. The author has contributed to research in topics: Antigen & Human serum albumin. The author has an hindex of 12, co-authored 21 publications receiving 573 citations. Previous affiliations of Maja Aleksic include Imperial College London & University of Liverpool.
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Journal ArticleDOI
Chemical reactivity measurement and the predicitve identification of skin sensitisers. The report and recommendations of ECVAM Workshop 64
Frank Gerberick,Maja Aleksic,David A. Basketter,Silvia Casati,Ann-Therese Karlberg,Petra S. Kern,Ian Kimber,Jean Pierre Lepoittevin,Andreas Natsch,Jean Marc Ovigne,Costanza Rovida,Hitoshi Sakaguchi,Terry W Schultz +12 more
TL;DR: A number of recommendations listed at the end of the report are intended to promote the progress of relevant and reliable methods toward prevalidation and validation.
Journal ArticleDOI
Reactivity profiling: covalent modification of single nucleophile peptides for skin sensitization risk assessment.
Maja Aleksic,Emma Thain,Delphine Roger,Ouarda Saib,Michael Davies,Jin Li,Aynur O. Aptula,Raniero Zazzeroni +7 more
TL;DR: The ultimate aim is to integrate this dataset with available physicochemical data and outputs from other predictive assays, all addressing different key steps in the induction of sensitization, to help us make decisions about the safe use of chemicals without using animal tests.
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Characterization of p-Phenylenediamine-Albumin Binding Sites and T-Cell Responses to Hapten-Modified Protein
Claire Jenkinson,Rosalind E. Jenkins,Maja Aleksic,Munir Pirmohamed,Dean J. Naisbitt,B. Kevin Park +5 more
TL;DR: Data identify Cys as the single target for PPD-HSA binding, and show that PPD protein adducts are antigenic determinants in patients with contact dermatitis.
Journal ArticleDOI
Investigating protein haptenation mechanisms of skin sensitisers using human serum albumin as a model protein.
TL;DR: The data indicate that covalent haptenation is a prerequisite of skin sensitisation but not irritation and suggest that protein modifications are targeted to certain amino acids residing in chemical microenvironments conducive to reactivity within an intact protein.
Journal ArticleDOI
A mechanistic investigation into the irreversible protein binding and antigenicity of p-phenylenediamine.
Claire Jenkinson,Rosalind E. Jenkins,James L. Maggs,Neil R. Kitteringham,Maja Aleksic,B. Kevin Park,Dean J. Naisbitt +6 more
TL;DR: Lymphocytes from PPD allergic patients were capable of discriminating between the different haptenic structures, suggesting that the hapten, but not the peptide moiety associated with MHC, is an important determinant for T-cell recognition.