I
Ian Kimber
Researcher at University of Manchester
Publications - 629
Citations - 30499
Ian Kimber is an academic researcher from University of Manchester. The author has contributed to research in topics: Local lymph node assay & Sensitization. The author has an hindex of 91, co-authored 620 publications receiving 28629 citations. Previous affiliations of Ian Kimber include University of Cambridge & Liverpool John Moores University.
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Journal ArticleDOI
Mechanistic applicability domain classification of a local lymph node assay dataset for skin sensitization.
David W. Roberts,Grace Patlewicz,Petra S. Kern,Frank Gerberick,Ian Kimber,Rebecca J. Dearman,Cindy A. Ryan,David A. Basketter,Aynur O. Aptula +8 more
TL;DR: It is shown that assignment to a reaction mechanistic domain is a critical first step in a strategic approach to understanding, ultimately on a quantitative basis, how chemical properties influence the potency of skin sensitizing chemicals.
Journal ArticleDOI
Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010
Sarah Adler,David A. Basketter,Stuart Creton,Olavi Pelkonen,Jan van Benthem,Valérie Zuang,Klaus Ejner Andersen,Alexandre Angers-Loustau,Aynur O. Aptula,Anna Bal-Price,Emilio Benfenati,Ulrike Bernauer,J.G.M. Bessems,Frédéric Y. Bois,Alan R. Boobis,Esther Brandon,Susanne Bremer,Thomas H. Broschard,Silvia Casati,Sandra Coecke,Raffaella Corvi,Mark T. D. Cronin,George P. Daston,Wolfgang Dekant,Susan P. Felter,Elise Grignard,Ursula Gundert-Remy,Tuula Heinonen,Ian Kimber,Jos C. S. Kleinjans,Hannu Komulainen,Reinhard Kreiling,Joachim Kreysa,Sofia B. Leite,George Loizou,Gavin Maxwell,Paolo Mazzatorta,Sharon Munn,Stefan Pfuhler,Pascal Phrakonkham,Aldert H. Piersma,Albrecht Poth,Pilar Prieto,Guillermo Repetto,Vera Rogiers,Greet Schoeters,Michael Schwarz,Rositsa Serafimova,Hanna Tähti,Emanuela Testai,Joost H.M. van Delft,Henk Van Loveren,Mathieu Vinken,Andrew Worth,Jose-Manuel Zaldivar +54 more
TL;DR: In this paper, Adler et al. present a survey of the authors' work in the field of bioinformatics, including the following authors:Sarah AdlerDavid BasketterStuart CretonOlavi PelkonenJan van BenthemValerie Zuang • Klaus Ejner AndersenAlexandre Angers-LoustauAynur AptulaAnna Bal-PriceEmilio Benfenati • Ulrike BernauerJos BessemsFrederic Y. BoisAlan BoobisEsther BrandonSusanne Bremer • Thomas
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Immunogenicity of therapeutic proteins: Influence of aggregation
TL;DR: An overview of the phenomenon of protein aggregation, the production of unwanted aggregates during bioprocessing, and how the immune response to aggregated protein differs from that provoked by non-aggregated protein is provided.
Journal ArticleDOI
Compilation of historical local lymph node data for evaluation of skin sensitization alternative methods
G. Frank Gerberick,Cindy A. Ryan,Petra S. Kern,Harald Schlatter,Rebecca J. Dearman,Ian Kimber,Grace Patlewicz,David A. Basketter +7 more
TL;DR: A database of robust in vivo data to calibrate, evaluate, and eventually validate new approaches for skin sensitization testing is provided, which represents both the chemical and biologic diversity that is known to exist for chemical allergens and non‐allergens.
Journal ArticleDOI
Food processing and allergenicity
Kitty C.M. Verhoeckx,Yvonne M. Vissers,Joseph L. Baumert,Roland Faludi,Marcel Feys,Simon Flanagan,Corinne Herouet-Guicheney,Thomas Holzhauser,R. Shimojo,Nieke van der Bolt,Harry J. Wichers,Ian Kimber +11 more
TL;DR: The overall conclusion drawn is that processing does not completely abolish the allergenic potential of allergens, and there remains a need to develop robust and integrated methods for the risk assessment of food allergenicity.