Malia B. Potts

TL;DR: A germline mechanism commonly hijacked in cancer to suppress AMPK through its ubiquitination and degradation by the cancer-specific MAGE-A3/6-TRIM28 ubiquitin ligase is described.

TL;DR: This approach identified gene products and natural product compounds that regulated processes as diverse as the breakdown of intracellular components, directed cell migration, and survival signaling, and holds promise for facilitating future drug discovery.

TL;DR: In the nematode C. elegans, the Hox gene mab-5 is required for the programmed cell deaths of two lineally related cells generated in the P11 and P12 lineages, and a complex between MAB-5 and the Pbx homolog CEH-20 directly regulates transcription of the BH3 domain gene egl-1 to initiate programmed cell death.

TL;DR: In this paper, the authors identified a family of alkaloid natural products, Discoipyrroles A-D (1−4), from Bacillus hunanensis that inhibit the DDR2 signaling pathway.

TL;DR: It is found that didemnin B selectively induces rapid and wholesale apoptosis through dual inhibition of PPT1 and EEF1A1 and this may facilitate patient selection that could enhance and expand therapeutic application of didem nin B against neoplastic disease.