Mana Alshehri

TL;DR: It is found that IL-33 expression in a large subset of human glioma specimens and murine models correlates with increased tumor-associated macrophages/monocytes/microglia, which supports the paradigm that recruitment and activation of immune cells, when instructed appropriately, offer a therapeutic strategy that switches the focus from the cancer cell alone to one that includes the normal host environment.

TL;DR: The results indicate that by assisting local lysosome/proteasome processes, CSPα-mediated removal of toxic proteins via EVs plays a central role in synaptic proteostasis and CSP α thus represents a potential therapeutic target for neurodegenerative diseases.

TL;DR: Evidence is provided that preventing phosphorylation of p75NTR on S303 by pharmacological inhibition of PKA, or by a mutational strategy (S303G), cripples p75nTR-mediated glioma invasion resulting in serine phosphorylated within the C-terminal PDZ-binding motif (SPV) of p 75NTR.

TL;DR: It is shown that Cic is strongly expressed in astrocytic and neuronal lineage cells during development and regulates proliferation and lineage selection via de-repression of Ets transcription factors.

TL;DR: It is concluded that DI is not selective for zipper-interacting protein kinase (ZIPK) and is a potent inhibitor of ROCKII.