Kimberly-Ann R. Goring

TL;DR: It is found that IL-33 expression in a large subset of human glioma specimens and murine models correlates with increased tumor-associated macrophages/monocytes/microglia, which supports the paradigm that recruitment and activation of immune cells, when instructed appropriately, offer a therapeutic strategy that switches the focus from the cancer cell alone to one that includes the normal host environment.

TL;DR: It is found that the development of pulmonary fibrosis depended on IL-17A and was significantly attenuated by neutrophil depletion, and it is established that nonlymphocytic innate immune cells, specifically neutrophils and monocytes/macrophages, rather than TH17 lymphocytes, are the predominant source of IL- 17A in experimental hypersensitivity pneumonitis.

TL;DR: Dipeptidase-1 (DPEP1) is established as a major adhesion receptor on the lung and liver endothelium and identified as a therapeutic target for neutrophil-driven inflammatory diseases of the lungs.

TL;DR: It is demonstrated that neutrophils are essential to facilitate the development of osteosarcoma pulmonary metastases and that treatment with the novel anti-inflammatory agent GM1-targeted linoleate-containing TLR2 ligand (GML), known to inhibit neutrophil recruitment, diminishes their occurrence.