K
Karlyne M. Reilly
Researcher at National Institutes of Health
Publications - 70
Citations - 3815
Karlyne M. Reilly is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 27, co-authored 58 publications receiving 3387 citations. Previous affiliations of Karlyne M. Reilly include Massachusetts Institute of Technology & Boston University.
Papers
More filters
Journal ArticleDOI
Mouse Models of Tumor Development in Neurofibromatosis Type 1
Karen Cichowski,Shih Ts,Earlene M. Schmitt,Santiago S,Karlyne M. Reilly,M E McLaughlin,Roderick T. Bronson,Tyler Jacks +7 more
TL;DR: These two mouse models provide the means to address fundamental aspects of disease development and to test therapeutic strategies, and demonstrate that loss of the wild-type Nf1 allele is rate-limiting in tumor formation.
Journal ArticleDOI
The genome architecture of the collaborative cross mouse genetic reference population
Fuad A. Iraqi,Mustafa Mahajne,Yasser Salaymah,Hani Sandovski,Hanna Tayem,Karin Vered,Lois Balmer,Michael R. Hall,Glynn Manship,Grant Morahan,Ken Pettit,Jeremy Scholten,Kathryn Tweedie,Andrew Wallace,Lakshini Weerasekera,James Cleak,Caroline Durrant,Leo Goodstadt,Richard Mott,Binnaz Yalcin,David L. Aylor,Ralph S. Baric,Timothy A. Bell,Katharine M. Bendt,J. Brennan,Jackie D. Brooks,Ryan J. Buus,James J. Crowley,John D. Calaway,Mark Calaway,Agnieszka Cholka,David B. Darr,John P. Didion,Amy Dorman,Eric T. Everett,Martin T. Ferris,Wendy Foulds Mathes,Chen Ping Fu,Terry J. Gooch,Summer G. Goodson,Lisa E. Gralinski,Stephanie D. Hansen,Mark T. Heise,Jane Hoel,Kunjie Hua,Mayanga C. Kapita,Seunggeun Lee,Alan B. Lenarcic,Eric Yi Liu,Hedi Liu,Leonard McMillan,Terry Magnuson,Kenneth F. Manly,Darla R. Miller,Deborah A. O'Brien,Fanny Odet,Isa Kemal Pakatci,Wenqi Pan,Fernando Pardo-Manuel de Villena,Charles M. Perou,Daniel Pomp,Corey R. Quackenbush,Nashiya N. Robinson,Norman E. Sharpless,Ginger D. Shaw,Jason S. Spence,Patrick F. Sullivan,Wei Sun,Lisa M. Tarantino,William Valdar,Jeremy Wang,Wei Wang,Catherine E. Welsh,Alan C. Whitmore,Tim Wiltshire,Fred A. Wright,Yuying Xie,Zaining Yun,Vasyl Zhabotynsky,Zhaojun Zhang,Fei Zou,Christine L. Powell,Jill Steigerwalt,David W. Threadgill,Elissa J. Chesler,Gary A. Churchill,Daniel M. Gatti,Ron Korstanje,Karen L. Svenson,Francis S. Collins,Nigel P.S. Crawford,Kent W. Hunter,N. Samir,P. Kelada,Bailey C.E. Peck,Karlyne M. Reilly,Urraca Tavarez,Daniel Bottomly,Robert Hitzeman,Shannon K. McWeeney,Jeffrey A. Frelinger,Harsha Krovi,Jason Phillippi,Richard A. Spritz,Lauri D. Aicher,Michael G. Katze,Elizabeth Rosenzweig,Ariel Shusterman,Aysar Nashef,Ervin I. Weiss,Yael Houri-Haddad,Morris Soller,Robert W. Williams,Klaus Schughart,Hyuna Yang,John E. French,Andrew K. Benson,Jaehyoung Kim,Ryan Legge,Soo Jen Low,Fangrui Ma,Inés Martínez,Jens Walter,Karl W. Broman,Benedikt Hallgrímsson,Ophir D. Klein,George M. Weinstock,Wesley C. Warren,Yvana V. Yang,David A. Schwartz +129 more
TL;DR: The Collaborative Cross Consortium reports here on the development of a unique genetic resource population, a multiparental recombinant inbred panel derived from eight laboratory mouse inbred strains, which shows that founder haplotypes are inherited at the expected frequency.
Journal ArticleDOI
Nf1 ; Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects
Karlyne M. Reilly,Dagan A. Loisel,Roderick T. Bronson,Margaret McLaughlin,Margaret McLaughlin,Tyler Jacks +5 more
TL;DR: This mouse model is the first reported mouse model of astrocytoma initiated by loss of tumour suppressors, rather than overexpression of transgenic oncogenes, and may accurately model human secondary glioblastoma involving TP53 loss.
Journal ArticleDOI
Histopathologic evaluation of atypical neurofibromatous tumors and their transformation into malignant peripheral nerve sheath tumor in patients with neurofibromatosis 1-a consensus overview.
Markku Miettinen,Cristina R. Antonescu,Christopher D.M. Fletcher,AeRang Kim,Alexander J. Lazar,Martha Quezado,Karlyne M. Reilly,Anat Stemmer-Rachamimov,Douglas R. Stewart,David Viskochil,Brigitte C. Widemann,Arie Perry +11 more
TL;DR: The term "atypical neurofibromatous neoplasms of uncertain biologic potential (ANNUBP)" is proposed for lesions displaying at least 2 of the histopathologic features involved in the malignant transformation of neurof fibromas, and should prompt additional sampling, clinical correlation, and possibly, expert pathology consultation.