M
Mandheer Wadhwa
Researcher at Duke University
Publications - 3
Citations - 161
Mandheer Wadhwa is an academic researcher from Duke University. The author has contributed to research in topics: DNA damage & Neuroprotection. The author has an hindex of 3, co-authored 3 publications receiving 93 citations.
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DNA damage by oxidative stress: Measurement strategies for two genomes
TL;DR: Although the field has made great strides in describing oxidative DNA damage and improving the overall sensitivity of standard techniques, many questions are still unanswered and substantial technical challenges remain; differential quantification and description of DNA damage (mitochondrial vs. nuclear) continues to be a challenge and a priority going forward.
Journal ArticleDOI
Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7
Colleen A. Stoyas,David D. Bushart,Pawel M. Switonski,Pawel M. Switonski,Jacqueline M. Ward,Akshay Alaghatta,Mi bo Tang,Mi bo Tang,Chenchen Niu,Mandheer Wadhwa,Haoran Huang,Alex Savchenko,Karim Gariani,Fang Xie,Joseph R. Delaney,Terry Gaasterland,Johan Auwerx,Vikram G. Shakkottai,Albert R. La Spada +18 more
TL;DR: Sirt1 achieves neuroprotection by promoting calcium regulation, and NAD+ dysregulation underlies Sirt1 dysfunction in SCA7, indicating that cerebellar ataxias exhibit altered calcium homeostasis because of metabolic dysregulation, suggesting shared therapy targets.
Journal ArticleDOI
Senataxin mutations elicit motor neuron degeneration phenotypes and yield TDP-43 mislocalization in ALS4 mice and human patients.
Craig L. Bennett,Somasish Ghosh Dastidar,Shuo-Chien Ling,Bilal Malik,Travis D. Ashe,Mandheer Wadhwa,Derek B. Miller,Changwoo Lee,Matthew B. Mitchell,Michael A. van Es,Christopher Grunseich,Yingzhang Chen,Bryce L. Sopher,Linda Greensmith,Don W. Cleveland,Don W. Cleveland,Albert R. La Spada +16 more
TL;DR: SETX ALS4 mice provided insight into the basis for TDP-43 histopathology, linking SETX dysfunction to common pathways of ALS motor neuron degeneration.