M
Mandy Madiredjo
Researcher at Netherlands Cancer Institute
Publications - 8
Citations - 3808
Mandy Madiredjo is an academic researcher from Netherlands Cancer Institute. The author has contributed to research in topics: RNA interference & Small hairpin RNA. The author has an hindex of 8, co-authored 8 publications receiving 3602 citations.
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A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer.
Katrien Berns,Hugo M. Horlings,Bryan T. Hennessy,Mandy Madiredjo,E. Marielle Hijmans,Karin Beelen,Sabine C. Linn,Ana M. Gonzalez-Angulo,Katherine Stemke-Hale,Michael Hauptmann,Roderick L. Beijersbergen,Gordon B. Mills,Marc J. van de Vijver,René Bernards +13 more
TL;DR: Assessment of PI3K pathway activation may provide a biomarker to identify patients unlikely to respond to trastuzumab-based therapy, and the combined analysis of PTEN and PIK3CA identified twice as many patients at increased risk for progression compared to PTEN alone.
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A large-scale RNAi screen in human cells identifies new components of the p53 pathway
Katrien Berns,E. Marielle Hijmans,Jasper Mullenders,Thijn R. Brummelkamp,Arno Velds,Mike Heimerikx,Ron M. Kerkhoven,Mandy Madiredjo,Wouter Nijkamp,Britta Weigelt,Reuven Agami,Wei Ge,Guy Cavet,Peter S. Linsley,Roderick L. Beijersbergen,René Bernards +15 more
TL;DR: The construction of a set of retroviral vectors encoding 23,742 distinct shRNAs, which target 7,914 different human genes for suppression, is reported, which confers resistance to both p53-dependent and p19ARF-dependent proliferation arrest, and abolishes a DNA-damage-induced G1 cell-cycle arrest.
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Human Immunodeficiency Virus Type 1 Escapes from RNA Interference-Mediated Inhibition
Atze T. Das,Thijn R. Brummelkamp,Ellen M. Westerhout,Monique Vink,Mandy Madiredjo,René Bernards,Ben Berkhout +6 more
TL;DR: It is reported here that an siRNA directed against the viral Nef gene (siRNA-Nef) confers resistance to HIV-1 replication, and RNAi could become a realistic gene therapy approach with which to overcome the devastating effect of HIV- 1 on the immune system.
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The ubiquitin-specific protease USP28 is required for MYC stability
Nikita Popov,Michael Wanzel,Mandy Madiredjo,Dong Zhang,Roderick L. Beijersbergen,René Bernards,Roland Moll,Stephen J. Elledge,Martin Eilers +8 more
TL;DR: The MYC proto-oncogene encodes a transcription factor that has been implicated in the genesis of many human tumours and one of these genes encodes USP28, an ubiquitin-specific protease required for MYC stability in human tumour cells.
Journal ArticleDOI
An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors
Thijn R. Brummelkamp,Armida W. M. Fabius,Jasper Mullenders,Mandy Madiredjo,Arno Velds,Ron M. Kerkhoven,René Bernards,Roderick L. Beijersbergen +7 more
TL;DR: The results suggest that nutlin-3's tumor specificity may result from its ability to turn a cancer cell–specific property (activated DNA damage signaling3) into a weakness that can be exploited therapeutically.