M
Manfred Schlachter
Researcher at Hoffmann-La Roche
Publications - 5
Citations - 565
Manfred Schlachter is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Resorption & Gene expression. The author has an hindex of 5, co-authored 5 publications receiving 539 citations.
Papers
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Journal ArticleDOI
Effect of EGCG on lipid absorption and plasma lipid levels in rats.
TL;DR: It is suggested that one of the underlying mechanisms by which EGCG affects lipid metabolism is by interfering with the micellar solubilization of cholesterol in the digestive tract, which then in turn decreased cholesterol absorption.
Journal ArticleDOI
Identification of hepatic molecular mechanisms of action of alpha-tocopherol using global gene expression profile analysis in rats.
Luca Barella,Patrick Y. Muller,Manfred Schlachter,Willi Hunziker,Elisabeth Stöcklin,Volker Spitzer,Nina Meier,Sonia de Pascual-Teresa,Anne Marie Minihane,Gerald Rimbach +9 more
TL;DR: Measurement of the corresponding biological endpoints such as activated partial thromboplastin time, plasma dihydrotestosterone and hepatic glutathione substantiated the gene chip data which indicated that dietary VE plays an important role in a range of metabolic processes within the liver.
Journal ArticleDOI
Reduced cavitation-induced cellular damage by the antioxidative effect of vitamin E
TL;DR: After the application of shock waves, cavitation-generated free radicals are demonstrated in cell-free solutions and also in the surviving and intact suspended MGH-U1 cells by hydroethidine measurements and under electron microscopical inspection.
Patent
Composition for the prevention of osteoporosis comprising a combination of isoflavones and polyunsaturated fatty acids
TL;DR: In this paper, the authors defined a composition, useful in the prevention of osteoporosis, wherein said composition comprises (a) at least one isoflavone and/or isoftlavone glycoside, preferably genistein and or genistin; (b) polyunsaturated fatty acid; (c) optionally vitamin D, and /or one or more derivatives thereof; (d) vitamin K, and optionally adjuvants and excipients in quantities as required, preferably within the range of 0.1 to 20 % by weight, based
Journal ArticleDOI
Biochemical bone turnover markers are useful tools to assess changes in bone metabolism in marmosets.
TL;DR: Although not all variables reached statistical significance within the tested interval, the applied methods and kits were considered suitable for evaluating bone turnover changes in marmosets and can be utilized not only during the course of pharmacological investigations but also as additional tools to assess the overall bone health of this species.