M
Manju Sharma
Researcher at Stanford University
Publications - 35
Citations - 3785
Manju Sharma is an academic researcher from Stanford University. The author has contributed to research in topics: Stem cell & Androgen receptor. The author has an hindex of 24, co-authored 35 publications receiving 3508 citations. Previous affiliations of Manju Sharma include University of Washington & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Plzf is required in adult male germ cells for stem cell self-renewal.
F. William Buaas,Andrew L Kirsh,Manju Sharma,Derek J. McLean,Jamie L Morris,Michael D. Griswold,Dirk G. de Rooij,Robert E. Braun +7 more
TL;DR: It is shown that the classical mouse mutant luxoid contains a nonsense mutation in the gene encoding Plzf, a transcriptional repressor that regulates the epigenetic state of undifferentiated cells, and this is the first gene shown to be required in germ cells for stem cell self-renewal in mammals.
Journal ArticleDOI
Functional Hierarchy and Reversibility Within the Murine Spermatogenic Stem Cell Compartment
Toshinori Nakagawa,Manju Sharma,Yo-ichi Nabeshima,Robert E. Braun,Shosei Yoshida,Shosei Yoshida,Shosei Yoshida +6 more
TL;DR: Using mice, Nakagawa et al. shed light on some of the properties of the murine germline stem cell system that contribute to its robustness and found that cysts are not committed to differentiation and appear to recover stem cell potential by fragmentation.
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Linking β-Catenin to Androgen-signaling Pathway
TL;DR: The data suggest that loss of E-cadherin can elevate the cellular levels of β-catenin in prostate cancer cells, which may directly contribute to invasiveness and a more malignant tumor phenotype by augmenting AR activity during prostate cancer progression.
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Phosphatidylinositol 3-Kinase/Akt Stimulates Androgen Pathway through GSK3β Inhibition and Nuclear β-Catenin Accumulation
TL;DR: A novel link among the PI3K, wnt, and androgen pathways is delineated and provided to provide fresh insights into the mechanisms of prostate tumor development and progression.
Journal ArticleDOI
TEX14 is essential for intercellular bridges and fertility in male mice
Michael P. Greenbaum,Wei Yan,Meng-Hsieh Wu,Yi-Nan Lin,Julio E. Agno,Manju Sharma,Robert E. Braun,Aleksandar Rajkovic,Martin M. Matzuk +8 more
TL;DR: It is shown that testis-expressed gene 14 (TEX14) is a novel protein that localizes to germ cell intercellular bridges in vertebrate germ cells, and these studies provide evidence that the inter cellular bridge is essential for spermatogenesis and fertility.