D
Dirk G. de Rooij
Researcher at Utrecht University
Publications - 306
Citations - 27195
Dirk G. de Rooij is an academic researcher from Utrecht University. The author has contributed to research in topics: Spermatogenesis & Sertoli cell. The author has an hindex of 86, co-authored 301 publications receiving 24983 citations. Previous affiliations of Dirk G. de Rooij include Wageningen University and Research Centre & Leiden University.
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Journal ArticleDOI
Regulation of cell fate decision of undifferentiated spermatogonia by GDNF.
Xiaojuan Meng,Maria Lindahl,Mervi E. Hyvönen,Martti Parvinen,Dirk G. de Rooij,Michael W. Hess,Anne Raatikainen-Ahokas,Kirsi Sainio,Heikki Rauvala,Merja Lakso,José G. Pichel,Heiner Westphal,Mart Saarma,Hannu Sariola +13 more
TL;DR: Transgenic loss-of-function and overexpression models show that the dosage of glial cell line-derived neurotrophic factor (GDNF), produced by Sertoli cells, regulates cell fate decisions of undifferentiated sperMatogonial cells that include the stem cells for spermatogenesis.
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MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline.
Michelle A. Carmell,Angélique Girard,Angélique Girard,Henk J. G. van de Kant,Déborah Bourc'his,Timothy H. Bestor,Dirk G. de Rooij,Gregory J. Hannon +7 more
TL;DR: The observations suggest a conserved function for Piwi-clade proteins in the control of transposons in the germline, and this work examines the effects of disrupting the gene encoding the third family member, MIWI2.
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All you wanted to know about spermatogonia but were afraid to ask.
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Plzf is required in adult male germ cells for stem cell self-renewal.
F. William Buaas,Andrew L Kirsh,Manju Sharma,Derek J. McLean,Jamie L Morris,Michael D. Griswold,Dirk G. de Rooij,Robert E. Braun +7 more
TL;DR: It is shown that the classical mouse mutant luxoid contains a nonsense mutation in the gene encoding Plzf, a transcriptional repressor that regulates the epigenetic state of undifferentiated cells, and this is the first gene shown to be required in germ cells for stem cell self-renewal in mammals.
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Sox9 induces testis development in XX transgenic mice.
TL;DR: It is shown that Sox9 is sufficient to induce testis formation in mice, indicating that it can substitute for the sex-determining gene Sry, which is associated with male-to-female sex reversal in humans.