M
Manju Swaroop
Researcher at National Institutes of Health
Publications - 46
Citations - 17398
Manju Swaroop is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Induced pluripotent stem cell & Gene. The author has an hindex of 28, co-authored 43 publications receiving 16652 citations. Previous affiliations of Manju Swaroop include University of Michigan & Yale University.
Papers
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Journal Article
Mdm2 ligase dead mutants did not act in a dominant negative manner to re-activate p53, but promoted tumor cell growth.
Manju Swaroop,Yi Sun +1 more
TL;DR: Test a hypothesis that Mdm2 ligase dead mutants, which retained p53 binding activity but lost degradation activity, would act in a dominant negative manner to re-activate p53, especially upon stressed conditions and found that expression of MDM2 mutants were tightly regulated by doxycycline.
Patent
Cyclodextrin for the treatment of lysosomal storage diseases
TL;DR: This paper used cyclodextrin compounds, including in combination with other therapeutics, including vitamin E, to treat lysosomal storage disorders and/or reduction of non-cholesterol lipids.
Journal ArticleDOI
Disease modeling for Mucopolysaccharidosis type IIIB using patient derived induced pluripotent stem cells.
TL;DR: In this article, induced pluripotent stem cell lines were established from two MPS IIIB patient fibroblast lines and differentiated into neural stem cells and neurons, which can be used as a cell-based disease model system for evaluation of drug efficacy and compound screening for drug development.
Journal ArticleDOI
iPS-derived neural stem cells for disease modeling and evaluation of therapeutics for mucopolysaccharidosis type II.
Junjie Hong,Yu Cheng,Shu Yang,Manju Swaroop,Miao Xu,Jeanette Beers,Jizhong Zou,Wenhua Huang,Juan J. Marugan,Xiujun Cai,Wei Zheng +10 more
TL;DR: In this article , three induced pluripotent stem cell (iPSC) lines were generated from three MPS II patient-derived dermal fibroblast cell lines that were differentiated into neural stem cells and neurons.
Journal ArticleDOI
Reserpine maintains photoreceptor survival in retinal ciliopathy by resolving proteostasis imbalance and ciliogenesis defects
Holly Y. Chen,Manju Swaroop,Samantha Papal,Anupam Mondal,Hyun Beom Song,Laura Campello,Gregory J. Tawa,Florian Regent,Hiroko Shimada,Kunio Nagashima,Natalia de Val,Samuel G. Jacobson,Wei Ping Zheng,Anand Swaroop +13 more
TL;DR: This study identifies effective drug candidates in preclinical studies of CEP290 retinal ciliopathy through cross-species drug discovery using iPSC-derived organoids, highlights the impact of proteostasis in the pathogenesis of ciliopathies, and provides new insights for treatments of retinal neurodegeneration.