Manju Swaroop

TL;DR: The secondary predicted from the deduced sequence of the Glued polypeptide has extensive alpha-helical internal domains, which contain heptad-repeat sequences characteristic of an elongated coiled-coil conformation.

TL;DR: A Lysotracker staining assay is developed that measures the enlarged lysosomes in patient-derived cells using both fluorescence intensity readout and fluorescence microscopic measurement and demonstrates that the LysotRacker assay can be used in compound screening for the identification of lead compounds that are capable of reducing enlarged lYSosomes for drug development.

TL;DR: HS is established as an attachment factor that assists SARS coronavirus cell entry, and drugs capable of targeting this important step in the viral life cycle are revealed.

TL;DR: The results, along with previous observations, suggest that SAG is an intracellular antioxidant molecule that may act as a redox sensor to buffer oxidative-stress induced damage.

TL;DR: Global chip profiling coupled with bioinformatics analysis is a powerful tool in identification of genes critical for p53-induced apoptosis and will lead to a better understanding of the mechanism of p53 action and p53 regulation of other signaling pathways.