Showing papers in "Experimental Cell Research in 2021"

TL;DR: The role of RBP DAZAP1 in hepatocellular carcinoma (HCC) was revealed in this article, where the relative expression of RBBP was significantly upregulated in HCC and was positively associated with several key malignant characteristics and poor postoperative survival in patients.

TL;DR: In this paper, the authors provided mechanistic insight into the pathology of diabetic retinopathy and identified TRIM46 and GPX4 as two molecular targets for the development of effective drugs for DR treatment.

TL;DR: In this article, miR-205-5p expression and microvessel densities (MVDs) in GC tissues and liver metastases from patients were investigated in vitro and in vivo.

TL;DR: It is found that high LDHC expression was significantly correlated with clinicopathological features of aggressive LUAD and a poor prognosis, and promotes proliferation, migration, invasion, and EMT in LUAD cells via activation of the PI3K/Akt/GSK-3β pathway.

TL;DR: Results show that SIRT1 not only reduced the non-epigenetic changes such as abnormal oocyte morphology, ROS accumulation, spindle defects and mitochondrial dysfunctions but also regulated the epigenetic changes in order to maintain the quality of postovulatory aged oocytes.

TL;DR: In this paper, the authors investigated the role of the froghead box M1 (FOXM1) in the protection of kidney tissue from acute kidney injury by driving tubular regeneration.

TL;DR: In this paper, the authors showed that RACGAP1 promoted mitochondrial fission through recruiting ECT2 during anaphase and subsequently activated ERK-DRP1 pathway.

TL;DR: In this paper, the authors discuss the causes of human senescence proteostasis decline, in view of the current literature on nematodes, on the one hand, and on the other hand, the relationship to senolytics.

TL;DR: Investigation of the antitumor activity of the outer membrane vesicles of Salmonella Typhimurium ATCC 14028 shows potential antitumour activity of ST-OMVs that might be used as a promising safe antitumors immunotherapy or an adjuvant to conventional chemotherapeutic drugs, resolving some of their problems.

TL;DR: In this article, a cell-permeable peptide corresponding to the NEMO-binding domain (NBD) of IKKα/β, termed NBD peptide, which disrupts NETs-mediated NF-κB interaction with IκB kinase (IKK) α/β and abolished NFκB activation in vitro.

TL;DR: The study indicated that the exosomes derived by HUVECs with AdET-1 infection can transfer miR-33 to macrophages and subsequently promote pro-inflammatory macrophage activation by directly targeting to NR4A and that ET-1 may act as a promising target for atherosclerosis management.

TL;DR: Wang et al. as mentioned in this paper showed that long noncoding RNAs (lncRNAs) play a crucial role in the onset and progression of cervical cancer (CC) and suggested new therapeutic targets in CC.

TL;DR: In this paper, the authors showed that hyperglycemia impairs mitochondrial dynamics and turnover, which may underlie the remarkable deterioration of mitochondrial respiration parameters in glomeruli and podocytes.

TL;DR: In this article, the authors evaluated whether EGT protects against UVB-induced photoaging using a keratinocyte/fibroblast co-culture system, and they found that EGT pretreatment of keratinocytes significantly inhibited downregulation of the Nrf2/HO-1 pathway and HSP70, and protected Keratinocytes by suppressing production of reactive oxygen species and cleavage of proapoptotic proteins, including caspase-8 and PARP.

TL;DR: In this article, the role of KLF5 in the proliferation and metastasis of melanoma was explored. But, the role in melanoma remains uncharacterized, and its role was not characterized in clinical tissues from melanoma patients.

TL;DR: It is demonstrated that intravitreal administration of MSC-exos ameliorates ONC-induced injury in a rat model and might aid in the development of effective exosome-based therapeutic strategies for the treatment of optic nerve degeneration.

TL;DR: In this paper, the role of miR-21 and its target androgen receptor in STZ-induced diabetic cardiac fibrosis was investigated, and it was shown that miR21−3p bound to the 3′UTR of AR post-transcriptionally repressed its expression.

TL;DR: In this article, the authors explore the effects on satellite cell function of pathogenic mutations in genes (myopathogenes) that associate with muscle disorders, to evaluate muscle pathological hallmarks that define dysfunctional satellite cells.

TL;DR: In this paper, the role of the PD-1/PD-L1 axis in macrophage polarization has been investigated, and it was shown that PD-L 1 binding to PD 1 promotes M2 polarization accompanied by mitochondrial function enhancement and metabolic reprogramming via Erk/Akt/mTOR.

TL;DR: In this article, the anti-tumor effects of new sorafenib derivatives-capped gold nanoparticles (AuNPs-New Sor) in tumor formation and metastasis as well as the underlying mechanisms were investigated.

TL;DR: In this article, the neuroprotective effects of normoxic and hypoxic bone marrow mesenchymal stromal cells-derived exosomes (N-BM-MSCs-Exo and H-BMMSCsExo, respectively) on oxygen-glucose deprivation (OGD) injury in mouse neuroblastoma N2a cells and rat primary cortical neurons were investigated.

TL;DR: Mechanistically, tumor HIF1α signaling activated by chemo-induced ROS drives the transcription of HMGB1 to promote more macrophage infiltration into CRC tumor, and provides novel drug targets for clinic treatments for CRC.

TL;DR: Wang et al. as mentioned in this paper investigated the role of Nrf2 in osteogenic differentiation of periodontal ligament stem cells (PDLSCs) under cyclic mechanical stretch.

TL;DR: The proximity between the endothelium and the new-forming cellular components of organs suggests an essential role of endothelial cells in the organs maturation.

TL;DR: In this article, the role of MEG3 in pulpitis was investigated using high-throughput sequencing to identify differentially expressed lncRNAs between human normal and inflamed pulp.

TL;DR: In this article, the role and molecular mechanism of TWIST2 in the occurrence and development of lung cancer was explored using RT-qPCR and western blotting, and the results revealed that TWIST 2 is lowly expressed in the tissues of patients and cell lines.

TL;DR: In this article, the authors quantified genome-wide DNA methylation of cultured human endothelial aortic cells (HAECs) via reduced-representation bisulfite sequencing (RRBS) following exposure to diabetic (250 mg/dL), pre-diabetic (125 mg/dL) or euglycemic (100 ǫ) glucose concentrations for 72h (n = 2).

TL;DR: In this article, microRNAs in tumor cell-derived exosomes were examined to investigate the communication between the bone environment and tumor cells, and it was shown that exosomal miR-17-5p is upregulated in a non-small cell lung cancer cell line with bone metastasis compared with the original cell line.

TL;DR: In this article, the role of NSUN2 in hypopharyngeal squamous cell carcinoma (HPSCC) was evaluated using a bioinformatics database, polymerase chain reaction, cell culture and transfection, immunohistochemistry, cell proliferation assay, wound healing experiments, transwell assays, western blotting, RNA-seq detection, dual-luciferase reporter assay, in vivo experiments, and a dot blot assay.

TL;DR: In this article, the authors summarized the different functions of lncRNAs in sepsis-induced cellular disorders, and showed the potential roles of some pivotal regulators in the pathogenesis of septicemia.