M
Manoj Thapa
Researcher at Emory University
Publications - 21
Citations - 775
Manoj Thapa is an academic researcher from Emory University. The author has contributed to research in topics: Chemokine & Immune system. The author has an hindex of 12, co-authored 21 publications receiving 629 citations. Previous affiliations of Manoj Thapa include University of Oklahoma Health Sciences Center & Yerkes National Primate Research Center.
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Journal ArticleDOI
Hepatic Stellate Cells Preferentially Induce Foxp3+ Regulatory T Cells by Production of Retinoic Acid
Richard M. Dunham,Manoj Thapa,Victoria M. Velazquez,Elizabeth Elrod,Timothy L. Denning,Bali Pulendran,Arash Grakoui +6 more
TL;DR: It is concluded that HSCs preferentially generate Foxp3+ Tregs and, therefore, may play a role in the tolerogenic nature of the liver.
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Susceptibility of CCR5-Deficient Mice to Genital Herpes Simplex Virus Type 2 Is Linked to NK Cell Mobilization
TL;DR: The absence of CCR5 expression significantly impacts the ability of the host to control genital HSV-2 infection, inflammation, and spread associated with a specific reduction in NK cell expansion, infiltration, and activity in the nervous system.
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CXCL9 and CXCL10 Expression Are Critical for Control of Genital Herpes Simplex Virus Type 2 Infection through Mobilization of HSV-Specific CTL and NK Cells to the Nervous System
TL;DR: The absence of CXCL9 or CxCL10 expression significantly alters the ability of the host to control genital HSV-2 infection through the mobilization of effector cells to sites of infection.
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Alterations in Intestinal Microbiota Lead to Production of Interleukin 17 by Intrahepatic γδ T-Cell Receptor–Positive Cells and Pathogenesis of Cholestatic Liver Disease
Dana Tedesco,Manoj Thapa,Chui Yoke Chin,Yong Ge,Minghao Gong,Jing Li,Sanjeev Gumber,Patrick Speck,Elizabeth Elrod,Eileen M. Burd,William H. Kitchens,Joseph F. Magliocca,Andrew B. Adams,David S. Weiss,Mansour Mohamadzadeh,Arash Grakoui +15 more
TL;DR: Development of liver fibrosis and inflammation to require hepatic activation of γδ TCR+ cells and production of IL17 mediated by exposure to L gasseri appears to contribute to development of cholestatic liver disease in patients.
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Intact TRL 9 and type I interferon signaling pathways are required to augment HSV-1 induced corneal CXCL9 and CXCL10.
TL;DR: This is the first report that shows enhanced CXCL10 expression following neurotropic viral replication requires both intact TLR 9 and type I interferon signaling pathways, and is correlative with an increase in virus shedding and a reduction in neutrophil infiltration.