Manuel Soriano-García

TL;DR: The purpose of this review is to discuss the recent pharmacological applications of organoselenium compounds as therapeutic agents in the treatment of several diseases.

TL;DR: It is shown that access to the pore of TRPV1 is gated by S6 in response to both capsaicin binding and increases in temperature, and that two constrictions are present inThe pore: one that impedes the access of large molecules and the other that hampers theAccess of smaller ions and constitutes an activation gate of these channels.

TL;DR: These studies showed that any mutations in the brake, including C456S, disrupted the structural integrity of the brake and its function to maintain these low voltage-activated channels closed at resting membrane potentials.

TL;DR: An antifungal peptide was isolated from Amaranthus hypochondriacus seeds by acidic extraction and then purified by reverse-phase high-pressure liquid chromatography, and it was found that Ay-AMP degrades chitin.

TL;DR: The purified product inhibited with E-64 was crystallized by sitting-drop vapour diffusion in the presence of ethanolamine and determined to be mexicain, a 23.7 kDa papain-like cysteine protease from the tropical plant Jacaratiamexicana.