Manuela Baronio

TL;DR: It is concluded that mutations in LRBA cause an immune deficiency characterized by defects in B cell activation and autophagy and by susceptibility to apoptosis, all of which are associated with a clinical phenotype of hypogammaglobulinemia and autoimmunity.

TL;DR: Adult human skeletal muscle includes a population of progenitor stem cells that can generate cells of the same lineage and cells with neurogenic properties, and may be a tissue source for the isolation of pluripotent stem cells for development of cell-based therapies for human myogenic and neurogenic diseases.

TL;DR: The findings indicate that the human embryonic aorta is a rich source of CD34+/CD31− endothelial progenitor cells (angioblasts), and this information may prove valuable in studies of vascular regeneration and tissue bioengineering.

TL;DR: A role for p17 in HIV-1 pathogenesis is defined and it is demonstrated that p17 was able to enhance levels of tumor necrosis factor α and IFN-γ released from cells stimulated by IL-2, and p17 restored the ability of cells to produce both cytokines.

TL;DR: BTK regulates human DC responses upon TLR9 engagement in terms of activation, cytokine production, and STAT1/3 upregulation, which may be of important significance for better understanding and managing different clinical conditions, such as agammaglobulinemia and lymphoid malignancies.