D
Dietmar Pfeifer
Researcher at University of Freiburg
Publications - 166
Citations - 12430
Dietmar Pfeifer is an academic researcher from University of Freiburg. The author has contributed to research in topics: Transplantation & Myeloid leukemia. The author has an hindex of 47, co-authored 154 publications receiving 10605 citations. Previous affiliations of Dietmar Pfeifer include University Medical Center Freiburg.
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Journal ArticleDOI
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor.
Erik-Oliver Glocker,Daniel Kotlarz,Kaan Boztug,E. Michael Gertz,Alejandro A. Schäffer,Fatih Noyan,Mario Perro,Jana Diestelhorst,Anna Allroth,Dhaarini Murugan,Nadine Hätscher,Dietmar Pfeifer,Karl-Walter Sykora,Martin Sauer,Hans Kreipe,Martin Lacher,Rainer Nustede,Cristina Woellner,Ulrich Baumann,Ulrich Salzer,Sibylle Koletzko,Neil Shah,Anthony W. Segal,Axel Sauerbrey,Stephan Buderus,Scott B. Snapper,Bodo Grimbacher,Christoph Klein +27 more
TL;DR: Mutations in genes encoding the IL10R subunit proteins were found in patients with early-onset enterocolitis, involving hyperinflammatory immune responses in the intestine, and resulted in disease remission in one patient.
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Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages.
Christoph S.N. Klose,Christoph S.N. Klose,Melanie Flach,Melanie Flach,Luisa Möhle,Leif Rogell,Leif Rogell,Leif Rogell,Thomas Hoyler,Thomas Hoyler,Karolina Ebert,Karolina Ebert,Carola Fabiunke,Carola Fabiunke,Dietmar Pfeifer,Veronika Sexl,Diogo Fonseca-Pereira,Rita G. Domingues,Henrique Veiga-Fernandes,Sebastian J. Arnold,Meinrad Busslinger,Ildiko Rita Dunay,Yakup Tanriver,Andreas Diefenbach +23 more
TL;DR: Interestingly, the CHILP differentiated into ILC2 and ILC3 lineages, but not into conventional natural killer cells that have been considered an ILC1 subset, presenting evidence for a new ILC lineage that protects barrier surfaces against intracellular infections.
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The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells.
Thomas Hoyler,Christoph S.N. Klose,Abdallah Souabni,Adriana Turqueti-Neves,Dietmar Pfeifer,Emma L. Rawlins,David Voehringer,Meinrad Busslinger,Andreas Diefenbach +8 more
TL;DR: It is demonstrated that GATA-3 is essential for ILC2 fate decisions and similarities between the transcriptional programs controlling ILC and T helper cell fates are revealed.
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A Homozygous CARD9 Mutation in a Family with Susceptibility to Fungal Infections
Erik-Oliver Glocker,André Hennigs,Mohammad Nabavi,Alejandro A. Schäffer,Cristina Woellner,Ulrich Salzer,Dietmar Pfeifer,Hendrik Veelken,Klaus Warnatz,F Tahami,Sarah Jamal,Annabelle Manguiat,Nima Rezaei,Ali Akbar Amirzargar,Alessandro Plebani,Nicole Hannesschläger,Olaf Gross,Jürgen Ruland,Bodo Grimbacher +18 more
TL;DR: Functional studies based on genetic reconstitution of myeloid cells from Card9(-/-) mice showed that the Q295X mutation impairs innate signaling from the antifungal pattern-recognition receptor dectin-1.
Journal ArticleDOI
New member of the winged-helix protein family disrupted in mouse and rat nude mutations
TL;DR: The whn gene, designated whn, encodes a new member of the winged-helix domain family of transcription factors and is disrupted on mouse nu and rat rnuN alleles, the first member of this class of genes to be implicated in a specific developmental defect in vertebrates.