D
Doron Melamed
Researcher at Technion – Israel Institute of Technology
Publications - 49
Citations - 2240
Doron Melamed is an academic researcher from Technion – Israel Institute of Technology. The author has contributed to research in topics: B cell & Receptor editing. The author has an hindex of 23, co-authored 49 publications receiving 2015 citations. Previous affiliations of Doron Melamed include Rappaport Faculty of Medicine.
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Journal ArticleDOI
Deleterious Mutations in LRBA Are Associated with a Syndrome of Immune Deficiency and Autoimmunity
G Lopez-Herrera,Giacomo Tampella,Qiang Pan-Hammarström,Peer Herholz,Claudia M. Trujillo-Vargas,Claudia M. Trujillo-Vargas,Kanchan Phadwal,Anna Katharina Simon,Anna Katharina Simon,Michel Moutschen,Amos Etzioni,Adi Mory,Izhak Srugo,Doron Melamed,Kjell Hultenby,Chonghai Liu,Chonghai Liu,Manuela Baronio,Massimiliano Vitali,Pierre Philippet,Vinciane Dideberg,Asghar Aghamohammadi,Nima Rezaei,Victoria Enright,Likun Du,Ulrich Salzer,Hermann Eibel,Dietmar Pfeifer,Hendrik Veelken,Hans J. Stauss,Vassilios Lougaris,Alessandro Plebani,E. Michael Gertz,Alejandro A. Schäffer,Lennart Hammarström,Bodo Grimbacher +35 more
TL;DR: It is concluded that mutations in LRBA cause an immune deficiency characterized by defects in B cell activation and autophagy and by susceptibility to apoptosis, all of which are associated with a clinical phenotype of hypogammaglobulinemia and autoimmunity.
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Developmental Regulation of B Lymphocyte Immune Tolerance Compartmentalizes Clonal Selection from Receptor Selection
TL;DR: It is shown here that sensitivity to antigen-induced apoptosis arises relatively late in B cell development and is preceded by a functionally distinct developmental stage capable of receptor editing, which compartmentalizes clonal selection from receptor selection.
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Human CD19(+)CD25(high) B regulatory cells suppress proliferation of CD4(+) T cells and enhance Foxp3 and CTLA-4 expression in T-regulatory cells
TL;DR: Human Breg cells decrease the proliferation of CD4(+) T cells and also enhance the expression of Foxp3 and CTLA-4 in Treg cells by cell-to-cell contact.
Journal ArticleDOI
Distinct Signal Thresholds for the Unique Antigen Receptor–Linked Gene Expression Programs in Mature and Immature B Cells
TL;DR: It is demonstrated that signaling by B cell antigen receptors leads to distinct and mutually exclusive biologic responses in mature and immature B cells: upregulation of CD86, CD69, and MHC class II in mature cells and receptor editing in immature cells.
Journal ArticleDOI
B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging
Zohar Keren,Shulamit Naor,Shahar Nussbaum,Karin Golan,Tomer Itkin,Yoshiteru Sasaki,Marc Schmidt-Supprian,Tsvee Lapidot,Doron Melamed +8 more
TL;DR: The results suggest that immunosenescence in the B-lineage is not irreversible and that depletion of the long-lived B cells in old mice rejuvenates the B -lineage and enhances immune competence.