Manuela Pfeiffer

TL;DR: The cellular expression of SDF-1 isoforms and CXCR4 in the brain of mice receiving systemic lipopolysaccharide (LPS) or permanent focal cerebral ischemia is examined to find the isoform-specific regulation of S DF-1 expression modulates neurotransmission and cerebral infiltration via distinct CX CR4-dependent pathways.

TL;DR: In this article, the sst2A-sst3 heterodimer exhibited high affinity binding to somatostatin-14 and the Sst2-selective ligand L-779, 976 but not to the Sost3-selectively ligand l-796,778.

TL;DR: Dimmerization of the sst2A somatostatin receptor and the μ-opioid receptor, members of closely related G protein-coupled receptor families, is examined to provide direct evidence for heterodimerization of sst 2A and MOR1 in human embryonic kidney 293 cells.

TL;DR: It is shown that morphine promotes terminal MOR desensitization by inducing a persistent modification of Ser375, which is a selective phosphorylation of the carboxy‐terminal residue 375.

TL;DR: It is shown that somatostatin receptors profoundly differ in patterns of β-arrestin mobilization and endosomal sorting, which may provide important clues about the regulation of receptor responsiveness during long-term administration of som atostatin analogs.