Manyuan Dong

TL;DR: The results suggested that dietary FA and/or Qu significantly decreased short chain fatty acids and elevated oligosaccharides in the feces, implying that dietaryFA and Qu may modulate gut microbial community with inhibition of bacterial fermentation of dietary fibers.

TL;DR: In this article, the authors identify a mechanism linking intestinal Akkermansia muciniphila and the aryl hydrocarbon receptor (AHR) to saccharin/sucralose-induced nonalcoholic fatty liver disease (NAFLD) in mice.

TL;DR: Although TCC exhibited dose-dependent toxicity, oral exposure with relative low dose TCC caused more significant hepatic lipogenesis of rats than realtive high and moderate doses of TCC used in this study, providing new insights into health effects of T CC exposure with different dosages in vivo.

TL;DR: Targeted metabolomics combined with untargeted 1H NMR-based metabolomics found that TCDF exposure induced alteration of phospholipids and choline metabolites and endoplasmic reticulum (ER) markers in the liver of mice, indicating that disruption of host cell membrane structural integrity and ER stress leading to hepatic steatosis.

TL;DR: Fast and sensitive label-free quantitation with normalization of the acyl chain length to achieve more accurate quantification is developed.