C
Craig Horbinski
Researcher at Northwestern University
Publications - 266
Citations - 13424
Craig Horbinski is an academic researcher from Northwestern University. The author has contributed to research in topics: Glioma & Medicine. The author has an hindex of 55, co-authored 201 publications receiving 9167 citations. Previous affiliations of Craig Horbinski include University of California, Irvine & Cleveland Clinic.
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Journal ArticleDOI
Epidemiologic and Molecular Prognostic Review of Glioblastoma
Jigisha P. Thakkar,Therese A. Dolecek,Craig Horbinski,Quinn T. Ostrom,Donita Lightner,Jill S. Barnholtz-Sloan,John L. Villano +6 more
TL;DR: The current epidemiology of GBM is reported with new data from the Central Brain Tumor Registry of the United States 2006 to 2010 as well as demonstrate and discuss trends in incidence and survival.
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Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma.
Junfei Zhao,Andrew X. Chen,Robyn D. Gartrell,Andrew M. Silverman,Luis Aparicio,Tim Chu,Darius Bordbar,David Shan,Jorge Samanamud,Aayushi Mahajan,Ioan Filip,Rose Orenbuch,Morgan Goetz,Jonathan T. Yamaguchi,Michael Cloney,Craig Horbinski,Rimas V. Lukas,Jeffrey Raizer,Ali I Rae,Jinzhou Yuan,Peter Canoll,Jeffrey N. Bruce,Yvonne M. Saenger,Peter A. Sims,Fabio M. Iwamoto,Adam M. Sonabend,Raul Rabadan +26 more
TL;DR: This study shows that clinical response to anti-PD-1 immunotherapy in GBM is associated with specific molecular alterations, immune expression signatures, and immune infiltration that reflect the tumor’s clonal evolution during treatment.
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Regulation of Autophagy by Extracellular Signal- Regulated Protein Kinases During 1-Methyl-4- Phenylpyridinium-Induced Cell Death
TL;DR: It is demonstrated that MPP(+) elicited increased autophagy in SH-SY5Y cells, and a role for extracellular signal-regulated protein kinase (ERK) signaling upstream of MPP+-elicited autophagic stress is implicate.
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Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions
Patrick Y. Wen,Michael Weller,Eudocia Q. Lee,Brian M. Alexander,Jill S. Barnholtz-Sloan,Floris P. Barthel,Tracy T. Batchelor,Ranjit S. Bindra,Susan M. Chang,E. Antonio Chiocca,Timothy F. Cloughesy,John DeGroot,Evanthia Galanis,Mark R. Gilbert,Monika E. Hegi,Craig Horbinski,Raymond Y. Huang,Andrew B. Lassman,Emilie Le Rhun,Michael Lim,Minesh P. Mehta,Ingo K. Mellinghoff,Giuseppe Minniti,David Nathanson,Michael Platten,Matthias Preusser,Patrick Roth,Marc Sanson,David Schiff,Susan C Short,Martin J B Taphoorn,Joerg C. Tonn,Jonathan Tsang,Roel G.W. Verhaak,Andreas von Deimling,Wolfgang Wick,Gelareh Zadeh,David A. Reardon,Kenneth Aldape,Martin J. van den Bent +39 more
TL;DR: Novel therapies such as targeted molecular therapies, agents targeting DNA damage response and metabolism, immunotherapies and viral therapies will be reviewed, as well as the current challenges and future directions for research.
Journal ArticleDOI
CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells
Alan L. Chang,Jason Miska,Derek A. Wainwright,Mahua Dey,Claudia V. Rivetta,Dou Yu,Deepak Kanojia,Katarzyna C. Pituch,Jian Qiao,Peter Pytel,Yu Han,Meijing Wu,Lingjiao Zhang,Craig Horbinski,Atique U. Ahmed,Maciej S. Lesniak +15 more
TL;DR: It is reported that macrophages and microglia within the glioma microenvironment produce CCL2, a chemokine that is critical for recruiting both CCR4+ Treg and CCR2+Ly-6C+ monocytic MDSCs in this disease setting.