M
Malcolm Cook
Researcher at Stowers Institute for Medical Research
Publications - 20
Citations - 1398
Malcolm Cook is an academic researcher from Stowers Institute for Medical Research. The author has contributed to research in topics: Nucleation & Branchiostoma floridae. The author has an hindex of 11, co-authored 18 publications receiving 1161 citations. Previous affiliations of Malcolm Cook include University of Massachusetts Amherst.
Papers
More filters
Journal ArticleDOI
Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution
J. Joshua Smith,Shigehiro Kuraku,Carson Holt,Tatjana Sauka-Spengler,Ning Jiang,Michael S. Campbell,Mark Yandell,Tereza Manousaki,Axel Meyer,Ona Bloom,Ona Bloom,Jennifer R. Morgan,Joseph D. Buxbaum,Ravi Sachidanandam,Carrie Sims,Alexander S. Garruss,Malcolm Cook,Robb Krumlauf,Leanne M. Wiedemann,Stacia A. Sower,Wayne A. Decatur,Jeffrey A. Hall,Chris T. Amemiya,Nil Ratan Saha,Katherine M. Buckley,Jonathan P. Rast,Sabyasachi Das,Masayuki Hirano,Nathanael McCurley,Peng Guo,Nicolas Rohner,Clifford J. Tabin,Paul Piccinelli,Greg Elgar,Magali Ruffier,Bronwen Aken,Stephen M. J. Searle,Matthieu Muffato,Miguel Pignatelli,Javier Herrero,Matthew Jones,C. Titus Brown,Yu Wen Chung-Davidson,Kaben G. Nanlohy,Scot V. Libants,Chu Yin Yeh,David W. McCauley,James A. Langeland,Zeev Pancer,Bernd Fritzsch,Pieter J. de Jong,Baoli Zhu,Lucinda Fulton,Brenda Theising,Paul Flicek,Marianne E. Bronner,Wesley C. Warren,Sandra W. Clifton,Richard K. Wilson,Weiming Li +59 more
TL;DR: Analyses of the assembly indicate that two whole-genome duplications likely occurred before the divergence of ancestral lamprey and gnathostome lineages, and help define key evolutionary events within vertebrate lineages.
Journal ArticleDOI
The sea lamprey germline genome provides insights into programmed genome rearrangement and vertebrate evolution.
J. Joshua Smith,Nataliya Timoshevskaya,Chengxi Ye,Carson Holt,Melissa C. Keinath,Hugo J. Parker,Malcolm Cook,Jon E. Hess,Shawn R. Narum,Francesco Lamanna,Henrik Kaessmann,Vladimir A. Timoshevskiy,Courtney K. M. Waterbury,Cody Saraceno,Leanne M. Wiedemann,Leanne M. Wiedemann,Sofia M. C. Robb,Sofia M. C. Robb,Carl Baker,Evan E. Eichler,Dorit Hockman,Dorit Hockman,Tatjana Sauka-Spengler,Mark Yandell,Robb Krumlauf,Greg Elgar,Chris T. Amemiya,Chris T. Amemiya +27 more
TL;DR: A new assembly of the sea lamprey germline genome identifies genomic regions that are systematically eliminated from somatic tissue during early development and gives new insight into vertebrate evolution.
Journal ArticleDOI
The Mll2 branch of the COMPASS family regulates bivalent promoters in mouse embryonic stem cells.
Deqing Hu,Alexander S. Garruss,Xin Gao,Marc A. Morgan,Malcolm Cook,Edwin R. Smith,Ali Shilatifard +6 more
TL;DR: The identification of the Mll2 complex as the COMPASS family member responsible for H3K4me3 marking bivalently marked promoters in embryonic stem cells provides an opportunity to reevaluate and experimentally test models for the function of bivalency in the embryonic stem cell state and in differentiation.
Journal ArticleDOI
SR proteins control a complex network of RNA-processing events
TL;DR: Regulation of AS by the SR proteins is the result of combinatorial regulation by multiple SR protein family members on most endogenous targets, and SR proteins have a broader role in integrating multiple layers of gene expression regulation.
Journal ArticleDOI
Quantifying Nucleation In Vivo Reveals the Physical Basis of Prion-like Phase Behavior
Tarique Khan,Tejbir S. Kandola,Jianzheng Wu,Jianzheng Wu,Shriram Venkatesan,Ellen Ketter,Jeffrey J. Lange,Alejandro Rodriguez Gama,Andrew C. Box,Jay R. Unruh,Malcolm Cook,Randal Halfmann,Randal Halfmann +12 more
TL;DR: It is shown that kinetic barriers limit the nucleation of ordered self-assemblies and that the persistence of the barriers with respect to concentration relates to structure, suggesting that nucleation barriers govern cytoplasmic inheritance, subcellular organization, and proteotoxicity.