M
Marc D. Bullock
Researcher at University of Southampton
Publications - 31
Citations - 1715
Marc D. Bullock is an academic researcher from University of Southampton. The author has contributed to research in topics: Stromal cell & Cancer. The author has an hindex of 19, co-authored 27 publications receiving 1402 citations. Previous affiliations of Marc D. Bullock include University Hospital Southampton NHS Foundation Trust & Southampton General Hospital.
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Journal ArticleDOI
Exosomal microRNAs (exomiRs): Small molecules with a big role in cancer
Rahul Bhome,Filippo Del Vecchio,Gui-Han Lee,Marc D. Bullock,John N. Primrose,A. Emre Sayan,Alex H. Mirnezami +6 more
TL;DR: Mechanisms underpinning their actions, such as exomiR receptors (“miRceptors”), are now becoming apparent and are highly suitable candidates for use as non-invasive biomarkers in an era of personalized cancer medicine.
Journal ArticleDOI
A subset of myofibroblastic cancer-associated fibroblasts regulate collagen fiber elongation, which is prognostic in multiple cancers.
Christopher J. Hanley,Fergus Noble,Matthew J. Ward,Marc D. Bullock,Cole R. Drifka,Massimiliano Mellone,Antigoni Manousopoulou,Harvey E. Johnston,Annette Hayden,Stephen M. Thirdborough,Yuming Liu,David M. Smith,Toby Mellows,W. John Kao,Spiros D. Garbis,Alex H. Mirnezami,Timothy J. Underwood,Kevin W. Eliceiri,Gareth J. Thomas +18 more
TL;DR: It is shown that increased collagen fiber length correlates with poor patient survival in multiple tumor types and that only a sub-set of SMA-positive CAFs can mediate the formation of this collagen structure.
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Targeting the Myofibroblastic Cancer-Associated Fibroblast Phenotype Through Inhibition of NOX4
Christopher J. Hanley,Massimiliano Mellone,Kirsty Ford,S Thirdborough,Toby Mellows,Steven J Frampton,David M. Smith,Elena Harden,Cedric Szyndralewiez,Marc D. Bullock,Fergus Noble,Karwan A. Moutasim,Emma King,Pandurangan Vijayanand,Alex H. Mirnezami,Timothy J. Underwood,Christian H. Ottensmeier,Gareth J. Thomas +17 more
TL;DR: The data suggest that pharmacological inhibition of NOX4 may have broad applicability for stromal targeting across cancer types.
Journal ArticleDOI
MicroRNAs: critical regulators of epithelial to mesenchymal (EMT) and mesenchymal to epithelial transition (MET) in cancer progression
TL;DR: The understanding of EMT has been significantly improved by the characterization of miRNAs that influence the signalling pathways and downstream events that define EMT on a molecular level.
Journal ArticleDOI
miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance
Lei Zhang,Karen Pickard,Veronika Jenei,Marc D. Bullock,Amanda Bruce,Richard Mitter,Gavin Kelly,Christos Paraskeva,John Strefford,John N. Primrose,Gareth J. Thomas,Graham Packham,Alex H. Mirnezami +12 more
TL;DR: It is reported that miR-153 has a dual role during progression of colorectal cancer by enhancing cellular invasiveness and platinum-based chemotherapy resistance and rationalizing therapeutic strategies to target expression of this miRNA for coloreCTal cancer treatment.