F
Fergus Noble
Researcher at University of Southampton
Publications - 39
Citations - 1539
Fergus Noble is an academic researcher from University of Southampton. The author has contributed to research in topics: Cancer & Stromal cell. The author has an hindex of 19, co-authored 38 publications receiving 1182 citations. Previous affiliations of Fergus Noble include Southampton General Hospital & National Health Service.
Papers
More filters
Journal ArticleDOI
Cancer-associated fibroblasts predict poor outcome and promote periostin-dependent invasion in oesophageal adenocarcinoma
Timothy J. Underwood,Annette Hayden,Mathieu Derouet,Edwin Garcia,Fergus Noble,Michael J. White,S Thirdborough,Abbie Mead,Nicholas J. Clemons,Nicholas J. Clemons,Nicholas J. Clemons,Massimiliano Mellone,Chudy Uzoho,John N. Primrose,Jeremy P. Blaydes,Gareth J. Thomas +15 more
TL;DR: Most EACs contain a myofibroblastic CAF‐rich stroma; this may explain the aggressive, highly infiltrative nature of the disease, and suggests that stromal targeting may produce therapeutic benefit in EAC patients.
Journal ArticleDOI
A subset of myofibroblastic cancer-associated fibroblasts regulate collagen fiber elongation, which is prognostic in multiple cancers.
Christopher J. Hanley,Fergus Noble,Matthew J. Ward,Marc D. Bullock,Cole R. Drifka,Massimiliano Mellone,Antigoni Manousopoulou,Harvey E. Johnston,Annette Hayden,Stephen M. Thirdborough,Yuming Liu,David M. Smith,Toby Mellows,W. John Kao,Spiros D. Garbis,Alex H. Mirnezami,Timothy J. Underwood,Kevin W. Eliceiri,Gareth J. Thomas +18 more
TL;DR: It is shown that increased collagen fiber length correlates with poor patient survival in multiple tumor types and that only a sub-set of SMA-positive CAFs can mediate the formation of this collagen structure.
Journal ArticleDOI
Targeting the Myofibroblastic Cancer-Associated Fibroblast Phenotype Through Inhibition of NOX4
Christopher J. Hanley,Massimiliano Mellone,Kirsty Ford,S Thirdborough,Toby Mellows,Steven J Frampton,David M. Smith,Elena Harden,Cedric Szyndralewiez,Marc D. Bullock,Fergus Noble,Karwan A. Moutasim,Emma King,Pandurangan Vijayanand,Alex H. Mirnezami,Timothy J. Underwood,Christian H. Ottensmeier,Gareth J. Thomas +17 more
TL;DR: The data suggest that pharmacological inhibition of NOX4 may have broad applicability for stromal targeting across cancer types.
Journal ArticleDOI
Tumour infiltrating lymphocytes correlate with improved survival in patients with oesophageal adenocarcinoma
Fergus Noble,Fergus Noble,Toby Mellows,Leo H. McCormick Matthews,Adrian C Bateman,Scott Harris,Timothy J. Underwood,Timothy J. Underwood,James P. Byrne,Ian Bailey,D. Sharland,Jamie Kelly,John N. Primrose,John N. Primrose,Surinder S. Sahota,Andrew Bateman,Andrew Bateman,Gareth J. Thomas,Gareth J. Thomas,Christian H. Ottensmeier,Christian H. Ottensmeier +20 more
TL;DR: An association of TILs and survival in OAC is established, as seen in other solid tumours, and particular TIL subsets that are present at higher levels in patients who responded to NAC compared to non-responders are identified.
Journal ArticleDOI
Population-based cohort study of outcomes following cholecystectomy for benign gallbladder diseases
R S Vohra,Sandro Pasquali,Amanda Kirkham,Paul Marriott,Marianne Johnstone,Philip Spreadborough,Derek Alderson,Ewen A. Griffiths,Stephen W. Fenwick,Mohamed Elmasry,Quentin M. Nunes,David Kennedy,RB Khan,Mas Khan,Conor J. Magee,Steven M. Jones,Denise Mason,Ciny P. Parappally,P Mathur,Michael Saunders,Sara Jamel,S Ul Haque,Sara Zafar,MH Shiwani,Nehemiah Samuel,Farooq Dar,Andrew Jackson,Bryony Lovett,S. Dindyal,Hannah Winter,T Fletcher,Saquib Rahman,Kevin Wheatley,Tom Nieto,Soofiyah Ayaani,Haney Youssef,R Nijjar,Helen Watkin,David N Naumann,S Emeshi,Piyush B. Sarmah,Kathryn Lee,Nikita Joji,Jonathan Heath,Rebecca L. Teasdale,Chamindri Weerasinghe,Paul J. Needham,Hannah Welbourn,Luke Forster,David Finch,Jane M Blazeby,William B. Robb,Agk McNair,Alex Hrycaiczuk,Sritharan Kadirkamanathan,C-B Tang,Nvg Jayanthi,Nigel Noor,Brian Dobbins,Andrew J Cockbain,April Nilsen-Nunn,J R De Siqueira,Mike Pellen,Jonathan B. Cowley,W-M Ho,Miu,Timothy J. White,Kathryn A. Hodgkins,Alison Kinghorn,Matthew G. Tutton,Yahya A. Al-Abed,D. Menzies,Anwar Ahmad,Joanna Reed,Shabuddin Khan,David Monk,Louis J. Vitone,Ghulam Murtaza,Abraham Joel,Stephen Brennan,David Shier,Chao Zhang,Thusidaran Yoganathan,Steven J. Robinson,Ijd McCallum,Michael J. Jones,Mohammed Elsayed,Liz Tuck,J Wayman,Kate Carney,Somaiah Aroori,Kenneth B. Hosie,Adam Kimble,David M. Bunting,Adeshina S. Fawole,Mohammed Basheer,Rajiv V. Dave,J Sarveswaran,E Jones,Chris Kendal,Michael P. Tilston,Martin Gough,Tom Wallace,Shailendra Singh,J Downing,K. Mockford,Eyad Issa,Nimesh Shah,Neal Chauhan,Tim Wilson,A Forouzanfar,Jrl Wild,Emma Nofal,Catherine Bunnell,Khaliel Madbak,Stv Rao,L Devoto,N. Siddiqi,Zechan Khawaja,James Hewes,Laura Gould,Alice Chambers,Dan Rodriguez,Gourab Sen,Stuart Robinson,Francis Bartlett,David M. Rae,Tej Stevenson,Kas Sarvananthan,Simon J. Dwerryhouse,Simon M. Higgs,Oliver J. Old,Thomas J. Hardy,Reena Shah,S.T. Hornby,Ken Keogh,Lucinda Frank,Musallam Al-Akash,Emma A. Upchurch,Richard J. Frame,Michael J. Hughes,Clare Jelley,Simon Weaver,Shibendu Shekhar Roy,Toritseju O. Sillo,Giorgios Galanopoulos,Tamzin Cuming,P. Cunha,Salim Tayeh,Sarantos Kaptanis,Mohamed Heshaishi,Abdalla Eisawi,Michael Abayomi,Wee Sing Ngu,Katie Fleming,Dalvir Bajwa,Chitre,Kamal Aryal,Paul Ferris,Michael Silva,Simon Lammy,S Mohamed,Amir Khawaja,Ayyaz Hussain,Mudassar A. Ghazanfar,Maria Irene Bellini,Hamdi Ebdewi,Mohamed Elshaer,Gianpiero Gravante,Benjamin Drake,Arikoge Ogedegbe,Dilip Mukherjee,Chanpreet Arhi,Lgn Iqbal,N F S Watson,Smeer Kumar Aggarwal,Philippa Orchard,Eduardo Villatoro,Peter D. Willson,K Wa,J Mok,Timothy J. Woodman,Jean Deguara,Giuseppe Garcea,Benoy I. Babu,Ashley R. Dennison,Deep Malde,David Lloyd,S Satheesan,O Al-Taan,Alex Boddy,John P. Slavin,Robert P. Jones,Laura Ballance,Stratos Gerakopoulos,Periyathambi Jambulingam,Sami Mansour,Naomi Sakai,Acharya,Mohammed M. Sadat,Lawen Karim,David Larkin,Khalid Amin,Alamgir Khan,Jennifer Law,Saurabh Jamdar,Smith,Keerthika Sampat,Kathryn M. O'shea,Mangta Manu,Fotini M. Asprou,Nabeela S. Malik,Jessica Chang,Michael Lewis,Geoffrey P. Roberts,Babu Karavadra,Evangelos Photi,James C. Hewes,Daniel Urriza Rodriguez,Derek A. O'Reilly,Anthony J. Rate,Hema Sekhar,Lucy T. Henderson,Benjamin Z. Starmer,Peter O Coe,Sotonye Tolofari,J Barrie,G Bashir,Jake Sloane,Suroosh Madanipour,Constantine Halkias,Aej Trevatt,D. W. Borowski,Jane Hornsby,Michael J. Courtney,Keith Seymour,Helen Hawkins,Sadiq Bawa,Paul V. Gallagher,Alistair Reid,Peter A. Wood,JG Finch,J Parmar,E Stirland,James Gardner-Thorpe,Ahmed Al-Muhktar,Mark Peterson,Ali Majeed,Farrukh M. Bajwa,Jack Martin,Alfred Choy,Andrew Tsang,Naresh Pore,Andrew,Waleed Al-Khyatt,C Taylor,S Bhandari,Dhivya Subramanium,Skc Toh,N C Carter,Stuart Mercer,B Knight,S Tate,B Pearce,David Wainwright,Vijay,Swethan Alagaratnam,Sidhartha Sinha,Shamsi El-Hasani,AA Hussain,Bhattacharya,Nisheeth Kansal,Tani Fasih,Cerian F Jackson,Midhat N. Siddiqui,Imran A. Chishti,Imogen J. Fordham,Zeba N. Siddiqui,Harald Bausbacher,Ileana Geogloma,Kabita Gurung,George Tsavellas,Pradeep Basynat,A. K. Shrestha,Sanjoy Basu,Acm Harilingam,Mohamed Rabie,Mansoor Akhtar,Pradeep Kumar,Sadaf F. Jafferbhoy,Najam Hussain,Soulat Raza,Manzarul Haque,Imran Alam,Rabiya Aseem,S Patel,Mehek Asad,Michael Booth,William R. Ball,Cpj Wood,Ana C. Pinho-Gomes,Ambareen Kausar,Obeidallah,Joseph Varghase,Joshil Lodhia,Donal Bradley,C Rengifo,David Lindsay,Sivakumar Gopalswamy,I. G. Finlay,S Wardle,Naomi Bullen,S. Y. Iftikhar,Altaf Awan,Jamil Ahmed,Paul Leeder,G. Fusai,Giles Bond-Smith,Alicja Psica,Yogesh Puri,David Hou,Fergus Noble,Karoly Szentpali,J Broadhurst,Ravindra S. Date,Hossack,YL Goh,Paul Turner,Shetty,Manel Riera,Caw Macano,Anisha Sukha,Preston,Hoban,Daniel J. Puntis,Sophie V. Williams,Richard Krysztopik,James Kynaston,Jeremy Batt,Matthew Doe,Andrzej Goscimski,Gareth H. Jones,C Hall,Nick Carty,Sofoklis Panteleimonitis,Rohan T. Gunasekera,Arg Sheel,Hannah Lennon,Caroline Hindley,Mallikarjun Reddy,R Kenny,N Elkheir,Emma Rose McGlone,R Rajaganeshan,Kate Hancorn,Anita Hargreaves,Raj Prasad,D.A. Longbotham,Dhakshinamoorthy Vijayanand,Imeshi Wijetunga,Paul Ziprin,Christopher R. Nicolay,Geoffrey Yeldham,Edward Read,James A. Gossage,Rachel C Rolph,Husam Ebied,Manraj Phull,Mohammad A. Khan,Matthew Popplewell,Dimitrios Kyriakidis,Natasha Henley,Packer,Laura Derbyshire,Jonathan Porter,S Appleton,Marwan Farouk,Melvinder Basra,Neil A. Jennings,Shahda Ali,Kanakala,H Ali,Risha Lane,Richard Dickson-Lowe,Prizzi Zarsadias,Darius F. Mirza,Sonia Puig,K Al Amari,Dipti Vijayan,Robert P. Sutcliffe,Ravi Marudanayagam,Zayed Hamady,Abheesh R. Prasad,Abhilasha Patel,D Durkin,Parminder Kaur,Laura Bowen,James P. Byrne,Katherine Pearson,Theo G. Delisle,James Davies,Mark A. Tomlinson,Michelle A. Johnpulle,Corinna Slawinski,Andrew Macdonald,James Nicholson,Katy Newton,James Mbuvi,Ansar Farooq,BS Mothe,Zakhi Zafrani,Daniel Brett,James Francombe,James Barnes,Melanie Cheung,Ahmed Z. Al-Bahrani,Giuseppe Preziosi,Tomas Urbonas,Justin Alberts,Mekhlola Mallik,Krashna Patel,Ashvina Segaran,Triantafyllos Doulias,P. Sufi,Caroline Yao,Sarah Pollock,Antonio Manzelli,SA Wajed,Michail Kourkulos,Roberto Pezzuto,Martin Wadley,Emma Hamilton,Shameen Jaunoo,Robert Padwick,Mazin Sayegh,Richard C. Newton,Madhusoodhana K.R. Hebbar,Sameh F. Farag,John Spearman,Mohammed Hamdan,Conrad D'Costa,Christine Blane,Mathew Giles,Mark B. Peter,Natalie A. Hirst,T Hossain,A Pannu,Y El-Dhuwaib,Tem Morrison,Greg W. Taylor,Rle Thompson,Ken McCune,Paula Loughlin,Roger Lawther,Colman K. Byrnes,Duncan J. Simpson,Abi Mawhinney,Conor Warren,Damian McKay,Colin McIlmunn,S. T. Martin,Matthew MacArtney,Tom Diamond,Phil Davey,C. Jones,Joshua Michael Clements,Ruairi Digney,WM Chan,Stephen McCain,Sadaf Gull,Adam Janeczko,Emmet Dorrian,Andrew Harris,Suzanne Dawson,Dorothy Johnston,Barry J. Mcaree,Essam Ghareeb,Gareth J. Thomas,Martin Connelly,S McKenzie,Krzysztos Cieplucha,Gary Spence,William Jeffrey Campbell,Gareth Hooks,Neil Bradley,Adk Hill,John T. Cassidy,Michael R. Boland,Paul E. Burke,Deirdre M. Nally,Elmoataz Khogali,Wael Shabo,Edrin Iskandar,G. McEntee,Maeve A. O'Neill,Colin Peirce,Emma M. Lyons,Adrian W. O'Sullivan,Rohan Thakkar,Paul V. Carroll,Ivan Ivanovski,Paul Balfe,Matthew Lee,Des C. Winter,Michael E. Kelly,Emir Hoti,Donal Maguire,Priyadarssini Karunakaran,Justin Geoghegan,Sean T. Martin,F. McDermott,K.S. Cross,Fiachra Cooke,Saquib Zeeshan,James O. Murphy,Ken Mealy,Helen Mohan,Yuwaraja Nedujchelyn,Muhammad Fahad Ullah,Irfan Ahmed,Francesco Giovinazzo,James Milburn,Sarah Prince,Eleanor Brooke,Joanna Buchan,Ahmed Khalil,Elizabeth M. Vaughan,Michael I. Ramage,Roland C. Aldridge,Simon Gibson,Gary Nicholson,David G. Vass,Alan J. Grant,David J. Holroyd,Matthew Jones,Cmlr Sutton,Patrick O'Dwyer,Frida Nilsson,Beatrix Weber,Tracey K. Williamson,Kushik Lalla,Alice Bryant,C.R. Carter,Craig R. Forrest,David I. Hunter,Ahmad H. M. Nassar,Mavis N. Orizu,Katrina Knight,Haitham Qandeel,Stuart Suttie,Rowena Belding,Andrew McClarey,Alan T. Boyd,Gjk Guthrie,Pei J. Lim,Andreas Luhmann,Ajm Watson,CH Richards,Laura Nicol,Marta Madurska,Ewen M Harrison,K. Boyce,A Roebuck,Graeme Ferguson,Pradeep Pati,Msj Wilson,Faith Dalgaty,Laura Fothergill,Peter J. Driscoll,Kirsty L. Mozolowski,Banwell,Stephen P. Bennett,Paul N. Rogers,B. Skelly,Claire Rutherford,Ahmed K. Mirza,T Lazim,Hcc Lim,Diana Duke,T Ahmed,William D. Beasley,Wilkinson,Geta Maharaj,Cathy Malcolm,T H Brown,Guy Shingler,N. Mowbray,Rami Radwan,Paul Morcous,Simon Wood,Abbas Kadhim,Duncan J. Stewart,Andrew L. Baker,N Tanner,Hrishikesh Shenoy,S Hafiz,JA De Marchi,D Singh-Ranger,E Hisham,P Ainley,Stephen O'Neill,John D. Terrace,Sara Napetti,B Hopwood,T Rhys,O Kanavati,M Coats,D Aleksandrov,C. Kallaway,S Yahya,A Templeton,M Trotter,C Lo,Amrita Dhillon,N Heywood,Y Aawsaj,Alhafidz Hamdan,O Reece-Bolton,A McGuigan,Yousef Shahin,Ashraf Ali,A Luther,JA Nicholson,I Rajendran,M. Boal,J Ritchie,CS Grp,Wmr Collaborative +627 more
TL;DR: The aim was to describe the management of benign gallbladder disease and identify characteristics associated with all‐cause 30‐day readmissions and complications in a prospective population‐based cohort.