M
Marc D. de Smet
Researcher at Leiden University
Publications - 153
Citations - 5252
Marc D. de Smet is an academic researcher from Leiden University. The author has contributed to research in topics: Uveitis & Medicine. The author has an hindex of 32, co-authored 138 publications receiving 4361 citations. Previous affiliations of Marc D. de Smet include Katholieke Universiteit Leuven & National Institutes of Health.
Papers
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Journal ArticleDOI
The International Vitreomacular Traction Study Group classification of vitreomacular adhesion, traction, and macular hole.
Jay S. Duker,Peter K. Kaiser,Susanne Binder,Marc D. de Smet,Alain Gaudric,Elias Reichel,Srinivas R. Sadda,Jerry Sebag,Richard F. Spaide,Peter Stalmans +9 more
TL;DR: This classification system will support systematic diagnosis and management by creating a clinically applicable system that is predictive of therapeutic outcomes and is useful for the execution and analysis of clinical studies.
Journal ArticleDOI
Recent developments in optical coherence tomography for imaging the retina.
TL;DR: An overview of the most recent developments in the field of OCT imaging focussing on applications for the retina shows how promising are the developments in contrast-enhanced molecular optical imaging, for example with the use of scattering tuneable nanoparticles targeted at specific tissue or cell structures.
Journal ArticleDOI
Understanding uveitis: The impact of research on visual outcomes
Marc D. de Smet,Stephen Taylor,Stephen Taylor,Bahram Bodaghi,Elisabetta Miserocchi,Philip I. Murray,Uwe Pleyer,Manfred Zierhut,Talin Barisani-Asenbauer,Phuc LeHoang,Susan Lightman,Susan Lightman +11 more
TL;DR: The aims of this review are to summarize the state of clinical research in uveitis, to identify gaps in knowledge, and to propose new opportunities and methodologies for future developments in all aspects of Uveitis research, including epidemiology, economic impact analysis, diagnosis, therapeutics, and clinical study design.
Journal ArticleDOI
The angio-fibrotic switch of VEGF and CTGF in proliferative diabetic retinopathy.
E. J. Kuiper,Frans A. van Nieuwenhoven,Marc D. de Smet,Jan C. van Meurs,Michael W.T. Tanck,Noelynn Oliver,Ingeborg Klaassen,Cornelis J.F. Van Noorden,Roel Goldschmeding,Reinier O. Schlingemann +9 more
TL;DR: CTGF is primarily a pro-fibrotic factor in the eye, and a shift in the balance between CTGF and VEGF is associated with the switch from angiogenesis to fibrosis in proliferative retinopathy.
Journal ArticleDOI
Cellular immune responses of patients with uveitis to retinal antigens and their fragments.
Marc D. de Smet,Marc D. de Smet,Joyce Hisae Yamamoto,Joyce Hisae Yamamoto,Manabu Mochizuki,Manabu Mochizuki,Igal Gery,Igal Gery,Vijay K. Singh,Vijay K. Singh,T. Shinohara,T. Shinohara,Barbara Wiggert,Barbara Wiggert,Gerald J. Chader,Gerald J. Chader,Robert B. Nussenblatt,Robert B. Nussenblatt +17 more
TL;DR: Several patients were capable of responding to more than one epitope of the same antigen, which indicates that there are major differences between the experimental model and human autoimmune diseases in the response to autoantigens.