Marc Dellian

TL;DR: Tumor vessels in the model found that tumor vessels in this model were permeable to liposomes of up to 400 nm in diameter, suggesting that the cutoff size of the pores is between 400 and 600nm in diameter.

TL;DR: The first combined, high-resolution measurements of interstitial pH and pO2 profiles between adjacent vessels in a human tumor xenograft are reported, using fluorescence ratio imaging and phosphorescence quenching microscopy.

TL;DR: It is demonstrated that tumor vascular permeability can be reduced by neutralization of endogenous VEGF/ VPF and suggest that angiogenesis and the maintenance of integrity of tumor vessels require the presence of VEGf/VPF in the tissue microenvironment.

TL;DR: Evidence is found supporting the hypothesis that tumor cells rely on glutaminolysis for energy production and that the pentose phosphate pathway is highly active within tumor cells and suggesting that the tricarboxylic acid cycle is saturable and that different metabolic pathways are activated to provide for energyproduction and biosynthesis.

TL;DR: A new DPPGOG-based liposomal formulation enabling long circulation time combined with fast and efficient drug release under mild hyperthermia is presented, which adds positively to the results with lipid-grafted polyethylenglycol used thus far in temperaturesensitive liposomes and widens the possibilities for clinical applications.