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Neil S. Forbes
Researcher at University of Massachusetts Amherst
Publications - 61
Citations - 5733
Neil S. Forbes is an academic researcher from University of Massachusetts Amherst. The author has contributed to research in topics: Salmonella & Cancer cell. The author has an hindex of 29, co-authored 59 publications receiving 5072 citations. Previous affiliations of Neil S. Forbes include Life Sciences Institute & University of California, Berkeley.
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Glutathione-Mediated Delivery and Release Using Monolayer Protected Nanoparticle Carriers
TL;DR: It is demonstrated here the effective delivery of a dye payload into cells using 2-nm core gold nanoparticles, with release occurring via place exchange of glutathione onto the particle surface.
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Engineering the perfect (bacterial) cancer therapy
TL;DR: It is proposed that synthetic biology techniques can be used to solve many of the key challenges that are associated with bacterial therapies, such as toxicity, stability and efficiency, and can been used to tune their beneficial features, allowing the engineering of 'perfect' cancer therapies.
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Tuning payload delivery in tumour cylindroids using gold nanoparticles
TL;DR: It is shown that positively- and negatively-charged gold nanoparticles carrying either fluorescein or doxorubicin molecules move and localize differently in an in vitro three dimensional model of tumour tissue, suggesting that positive particles may be more effective for drug delivery because they are more significantly taken up by proliferating cells.
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Efficient Gene Delivery Vectors by Tuning the Surface Charge Density of Amino Acid-Functionalized Gold Nanoparticles
TL;DR: Nanoparticles functionalized with first generation lysine dendrons (NP-LysG1) were approximately 28-fold superior to polylysine in reporter gene expression and responsive to intracellular glutathione levels, providing a tool for controlled release and concomitant expression of DNA.
Journal Article
Acid Production in Glycolysis-impaired Tumors Provides New Insights into Tumor Metabolism
TL;DR: Evidence is found supporting the hypothesis that tumor cells rely on glutaminolysis for energy production and that the pentose phosphate pathway is highly active within tumor cells and suggesting that the tricarboxylic acid cycle is saturable and that different metabolic pathways are activated to provide for energyproduction and biosynthesis.