Showing papers by "Marc-Henri Stern published in 1998"
TL;DR: Allelic ATM inactivations by large deletions or mutations were found in approximately two thirds of T-PLL, and ATM is thus a tumor suppressor gene whose inactivation is a key event in the development ofT-cell prolymphocytic leukemias.
161 citations
TL;DR: Data demonstrate that p13(MTCP1) is an oncoprotein and that CD2-p13 transgenic mice represent the first animal model for mature T-PLL, and that Tcrb rearrangements demonstrated the monoclonal origin of these populations.
79 citations
TL;DR: The structure of p14 TCL1 has been determined at 2.5 a resolution by molecular replacement using the solution of p13 MTCP1, revealing p14 tcl1 to be an all-β protein consisting of an eight-stranded antiparallel β barrel with a novel topology.
39 citations
TL;DR: The three-dimensional solution structure of the recombinant p13MTCP1 determined by homonuclear proton two-dimensional NMR methods at 600 MHz consists of an orthogonal β-barrel, composed of eight antiparallel β-strands which present an original arrangement.
Abstract: The human oncoprotein p13
MTCP1
is coded by the MTCP1 gene, a gene involved in chromosomal translocations associated with T-cell prolymphocytic leukemia, a rare form of human leukemia with a mature T-cell phenotype. The primary sequence of p13
MTCP1
is highly and only homologous to that of p14
TCL1
, a product coded by the gene TCL1 which is also involved in T-cell prolymphocytic leukemia. These two proteins probably represent the first members of a new family of oncogenic proteins. We present the three-dimensional solution structure of the recombinant p13
MTCP1
determined by homonuclear proton two-dimensional NMR methods at 600 MHz. After proton resonance assignments, a total of 1253 distance restraints and 64 dihedral restraints were collected. The solution structure of p13
MTCP1
is presented as a set of 20 DYANA structures. The rmsd values with respect to the mean structure for the backbone and all heavy atoms for the conformer family are 1.07 ± 0.19 and 1.71 ± 0.17 A, when the structured core of the protein (residues 11–103) is considered. The solution structure of p13
MTCP1
consists of an orthogonal β-barrel, composed of eight antiparallel β-strands which present an original arrangement. The two β-pleated loops which emerge from this barrel might constitute the interaction surface with a potential molecular partner.
18 citations
TL;DR: In this article, a proteine oncogenique humaine codee par le gene MTCP1, exprime dans des leucemies prolymphocytaires a phenotype mature.
Abstract: La proteine oncogenique humaine est codee par le gene MTCP1, exprime dans des leucemies prolymphocytaires a phenotype mature. Sa structure 3D a ete resolue par RMN 2D homonucleaire. P13 MTCP1 est essentiellement composee de feuillets β antiparalleles qui s'organisent en un tonneau β orthogonal a huit brins.
2 citations