M
Marc Siladi
Researcher at Eli Lilly and Company
Publications - 5
Citations - 249
Marc Siladi is an academic researcher from Eli Lilly and Company. The author has contributed to research in topics: Antitoxin & Amino acid. The author has an hindex of 4, co-authored 5 publications receiving 233 citations. Previous affiliations of Marc Siladi include Salk Institute for Biological Studies & Scripps Research Institute.
Papers
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Journal ArticleDOI
Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21
Timo D. Müller,Lorraine Sullivan,Kirk M. Habegger,Chun-Xia Yi,Dhiraj G. Kabra,Erin Grant,Nickki Ottaway,Radha Krishna,Jenna Holland,Jazzminn Hembree,Diego Perez-Tilve,Paul T. Pfluger,Michael Deguzman,Marc Siladi,Vadim Kraynov,Douglas W. Axelrod,Richard D. DiMarchi,Jason Pinkstaff,Matthias H. Tschöp +18 more
TL;DR: It is found that a hypothalamic counter‐regulatory response to weight loss, assessed using changes in hypothalamic agouti related peptide levels, is triggered by caloric restriction, but blunted by treatment with exendin‐4, concluding that leptin re‐sensitization requires pharmacotherapy but does not appear to be restricted to a unique signaling pathway.
Journal ArticleDOI
A viral nanoparticle with dual function as an anthrax antitoxin and vaccine.
Darly J. Manayani,Diane Thomas,Kelly A. Dryden,Vijay S. Reddy,Marc Siladi,John M. Marlett,G. Jonah A. Rainey,Michael E. Pique,Heather M. Scobie,Mark Yeager,Mark Yeager,John A. T. Young,Marianne Manchester,Anette Schneemann +13 more
TL;DR: This recombinant VLP platform represents a novel and highly effective, dually-acting reagent for treatment and protection against anthrax.
Patent
Modified animal erythropoietin polypeptides and their uses
Feng Tian,Anna-Maria A. Hays Putnam,Frank Song,Stephanie Chu,Joseph Sheffer,Richard S. Barnett,Marc Siladi,Kyle Atkinson,Darin Lee,Peter C. Canning +9 more
TL;DR: In this paper, a feline erythropoietin (fEPO) polypeptide comprising a non-naturally encoded amino acid substituted at a position corresponding to position 1 of SEQ ID NO: 2.601659
Patent
ANTI-FcεRI POLYPEPTIDES AND THEIR USES
TL;DR: Novel antigen-binding polypeptides (FcERI-ABP) having one or more non-naturally occurring amino acids, and uses thereof are provided in this paper.
Patent
Antitoxin and vaccine platform based on nodavirus VLPS
John A. T. Young,Anette Schneemann,Marianne Manchester,Kelly Dryden,John M. Marlett,Darly Joseph Manayani,Godfrey Jonah Anderson Rainey,Vijay Reddy,Marc Siladi,Heather M. Scobie,Diane Thomas,Mark Yeager +11 more
TL;DR: In this article, the authors provided methods of treating toxins with VLP-based antitoxins and raising an immune response with immunogen decorated VLPs, and vaccine compositions were provided.