J
John M. Marlett
Researcher at Salk Institute for Biological Studies
Publications - 17
Citations - 1608
John M. Marlett is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Anthrax toxin & Bacillus anthracis. The author has an hindex of 12, co-authored 17 publications receiving 1393 citations. Previous affiliations of John M. Marlett include Sanford-Burnham Institute for Medical Research.
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Journal ArticleDOI
Global landscape of HIV-human protein complexes
Stefanie Jäger,Peter Cimermancic,Peter Cimermancic,Natali Gulbahce,Natali Gulbahce,Jeffrey R. Johnson,Jeffrey R. Johnson,Jeffrey R. Johnson,Kathryn E. McGovern,Kathryn E. McGovern,Starlynn Clarke,Michael Shales,Michael Shales,Gaelle Mercenne,Lars Pache,Kathy H. Li,Kathy H. Li,Hilda Hernandez,Hilda Hernandez,Gwendolyn M. Jang,Gwendolyn M. Jang,Shoshannah L. Roth,Eyal Akiva,Eyal Akiva,John M. Marlett,Melanie L. Stephens,Iván D'Orso,Iván D'Orso,Jason D Fernandes,Marie E. Fahey,Marie E. Fahey,Cathal Mahon,Cathal Mahon,Anthony J. O’Donoghue,Aleksandar Todorovic,John H. Morris,David Maltby,Tom Alber,Gerard Cagney,Frederic D. Bushman,John A. T. Young,Sumit K. Chanda,Wesley I. Sundquist,Tanja Kortemme,Tanja Kortemme,Ryan D. Hernandez,Ryan D. Hernandez,Charles S. Craik,Charles S. Craik,Alma L. Burlingame,Alma L. Burlingame,Andrej Sali,Alan D. Frankel,Alan D. Frankel,Nevan J. Krogan +54 more
TL;DR: The use of affinity tagging and purification mass spectrometry is reported to determine systematically the physical interactions of all 18 HIV-1 proteins and polyproteins with host proteins in two different human cell lines (HEK293 and Jurkat).
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Use of the CRISPR/Cas9 system as an intracellular defense against HIV-1 infection in human cells
Hsin-Kai Liao,Ying Gu,Arturo Diaz,John M. Marlett,Yuta Takahashi,Mo Li,Keiichiro Suzuki,Ruo Xu,Tomoaki Hishida,Chan Jung Chang,Concepcion Rodriguez Esteban,John A. T. Young,Juan Carlos Izpisua Belmonte +12 more
TL;DR: It is shown that engineered human-induced pluripotent stem cells stably expressing HIV-targeted CRISPR/Cas9 can be efficiently differentiated into HIV reservoir cell types and maintain their resistance to HIV-1 challenge.
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In Situ Gene Therapy via AAV-CRISPR-Cas9-Mediated Targeted Gene Regulation.
Ana M. Moreno,Xin Fu,Jie Zhu,Jie Zhu,Dhruva Katrekar,Yu Ru V. Shih,John M. Marlett,Jessica Cabotaje,Jasmine Tat,John Naughton,Leszek Lisowski,Shyni Varghese,Kang Zhang,Kang Zhang,Kang Zhang,Prashant Mali +15 more
TL;DR: The AAV-CRISPR-Cas9 platform for in vivo epigenome engineering enables a robust approach to target disease in a genomically scarless and potentially reversible manner.
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BIRC2/cIAP1 Is a Negative Regulator of HIV-1 Transcription and Can Be Targeted by Smac Mimetics to Promote Reversal of Viral Latency
Lars Pache,Miriam S. Dutra,Adam M. Spivak,John M. Marlett,Jeffrey P. Murry,Young Hwang,Ana M. Maestre,Lara Manganaro,Mitchell Vamos,Peter Teriete,Laura J. Martins,Renate König,Renate König,Viviana Simon,Alberto Bosque,Ana Fernandez-Sesma,Nicholas D. P. Cosford,Frederic D. Bushman,John A. T. Young,Vicente Planelles,Sumit K. Chanda +20 more
TL;DR: Treatment of resting CD4+ T cells isolated from ART-suppressed patients with the histone deacetylase inhibitor (HDACi) panobinostat together with Smac mimetics resulted in synergistic activation of the latent reservoir, implicate Smac Mimetics as useful agents for shock-and-kill strategies to eliminate the latent HIV reservoir.
Journal ArticleDOI
A Soluble Receptor Decoy Protects Rats against Anthrax Lethal Toxin Challenge
Heather M. Scobie,Diane Thomas,John M. Marlett,Giuseppe Destito,Giuseppe Destito,Darran J. Wigelsworth,R. John Collier,John A. T. Young,Marianne Manchester +8 more
TL;DR: It is shown that, in a tissue-culture model of intoxication, sCMG2 is a 11.4-fold more potent antitoxin than sATR/TEM8 and that this increased activity corresponds to an approximately 1000-fold higher PA-binding affinity.