Marc Suling

TL;DR: Fetal macrosomia, also in the absence of maternal/gestational diabetes, is independently associated with the development of overweight/obesity during childhood and improving the understanding of fetal programming will contribute to the early prevention of childhood overweight/OBesity.

TL;DR: A comparison of hd-PS matching versus conventional PS matching resulted in improved point estimates for studying an intended treatment effect of coxibs versus tNSAIDs when benchmarked against results from randomized controlled trials.

TL;DR: The most commonly applied signal detection algorithms are presented, covering simple frequentistic methods like the proportional reporting rate or the reporting odds ratio, more advanced Bayesian techniques for spontaneous and longitudinal data, and a drug monitoring technique based on Wald’s sequential probability ratio test.

TL;DR: Extensive pretesting, training and subsequent refinement of the methods were necessary to assess the feasibility of all instruments and procedures in routine fieldwork and to exchange or modify procedures that would otherwise give invalid or misleading results.

TL;DR: This study aimed to develop an algorithm for linkage of mother–baby pairs in the German Pharmacoepidemiological Research Database (GePaRD) as a prerequisite for studies to investigate potential drug risks in pregnancy.