Marc Winnefeld

TL;DR: This work investigated the short-term metabolic response in human skin fibroblasts and keratinocytes to H2O2 and UV exposure and identified metabolic rerouting in oxidative and non-oxidative PPP has important physiological roles in stabilization of the redox balance and ROS clearance.

TL;DR: An array-based analysis to determine genome-scale DNA methylation patterns from human skin samples and to investigate the effects of aging, chronic sun exposure, and tissue variation reveals a high degree of tissue specificity in themethylation patterns and also showed very little interindividual variation within tissues.

TL;DR: The results suggest that the core developmental program of human skin is stably maintained through the aging process and that aging is associated with a limited destabilization of the epigenome at gene regulatory elements.

TL;DR: An age‐related erosion of DNA methylation patterns that is characterized by a reduced dynamic range and increased heterogeneity of globalmethylation patterns is uncovered, defining the loss of epigenetic regulatory fidelity as a key feature of the aging epigenome.

TL;DR: White Tea extract is a natural source that effectively inhibits adipogenesis and stimulates lipolysis-activity and can be utilized to modulate different levels of the adipocyte life cycle.