M
Marcel Dettling
Researcher at Zürcher Fachhochschule
Publications - 28
Citations - 13484
Marcel Dettling is an academic researcher from Zürcher Fachhochschule. The author has contributed to research in topics: Boosting (machine learning) & Customer lifetime value. The author has an hindex of 11, co-authored 27 publications receiving 12776 citations. Previous affiliations of Marcel Dettling include ETH Zurich & Winterthur Museum, Garden and Library.
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Journal ArticleDOI
Bioconductor: open software development for computational biology and bioinformatics
Robert Gentleman,Vincent J. Carey,Douglas M. Bates,Benjamin M. Bolstad,Marcel Dettling,Sandrine Dudoit,Byron Ellis,Laurent Gautier,Yongchao Ge,Jeff Gentry,Kurt Hornik,Torsten Hothorn,Wolfgang Huber,Stefano Maria Iacus,Rafael A. Irizarry,Friedrich Leisch,Cheng Li,Martin Maechler,A. J. Rossini,Günther Sawitzki,Colin A. Smith,Gordon K. Smyth,Luke Tierney,Jean Yang,Jianhua Zhang +24 more
TL;DR: Details of the aims and methods of Bioconductor, the collaborative creation of extensible software for computational biology and bioinformatics, and current challenges are described.
Journal ArticleDOI
BagBoosting for tumor classification with gene expression data
TL;DR: When bagging is used as a module in boosting, the resulting classifier consistently improves the predictive performance and the probability estimates of both bagging and boosting on real and simulated gene expression data.
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Gene Expression Signatures Identify Rhabdomyosarcoma Subtypes and Detect a Novel t(2;2)(q35;p23) Translocation Fusing PAX3 to NCOA1
Marco Wachtel,Marcel Dettling,E. Koscielniak,Sabine Stegmaier,Jörn Treuner,Katja Simon-Klingenstein,Peter Bühlmann,Felix Niggli,Beat W. Schäfer +8 more
TL;DR: The alveolar rhabdomyosarcoma signature was used to classify an additional alveolars case lacking any known PAX3 or PAX7 fusion as belonging to the translocation-positive group, leading to the identification of a novel translocation t(2;2)(q35;p23), which generates a fusion protein composed of PAX3 and the nuclear receptor coactivator NCOA1, having similar transactivation properties as PAX3/FKHR.
Journal ArticleDOI
Supervised clustering of genes
Marcel Dettling,Peter Bühlmann +1 more
TL;DR: A new method for finding groups of genes by directly incorporating the response variables into the grouping process, yielding a supervised clustering algorithm for genes that identifies gene clusters with excellent predictive potential.
Journal ArticleDOI
Finding predictive gene groups from microarray data
Marcel Dettling,Peter Bühlmann +1 more
TL;DR: Pelora is presented, an algorithm based on penalized logistic regression analysis, that combines gene selection, gene grouping and sample classification in a supervised, simultaneous way and identifies gene groups whose expression centroids have very good predictive potential and yield results that can keep up with state-of-the-art classification methods based on single genes.