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Yongchao Ge
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 78
Citations - 16517
Yongchao Ge is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Medicine & DNA methylation. The author has an hindex of 26, co-authored 65 publications receiving 14933 citations. Previous affiliations of Yongchao Ge include University of California, Berkeley.
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Journal ArticleDOI
Bioconductor: open software development for computational biology and bioinformatics
Robert Gentleman,Vincent J. Carey,Douglas M. Bates,Benjamin M. Bolstad,Marcel Dettling,Sandrine Dudoit,Byron Ellis,Laurent Gautier,Yongchao Ge,Jeff Gentry,Kurt Hornik,Torsten Hothorn,Wolfgang Huber,Stefano Maria Iacus,Rafael A. Irizarry,Friedrich Leisch,Cheng Li,Martin Maechler,A. J. Rossini,Günther Sawitzki,Colin A. Smith,Gordon K. Smyth,Luke Tierney,Jean Yang,Jianhua Zhang +24 more
TL;DR: Details of the aims and methods of Bioconductor, the collaborative creation of extensible software for computational biology and bioinformatics, and current challenges are described.
Journal ArticleDOI
Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome
Xonia Carvajal-Vergara,Ana Sevilla,Sunita L. D’Souza,Yen-Sin Ang,Christoph Schaniel,Dung Fang Lee,Lei Yang,Aaron D. Kaplan,Eric Adler,Roye Rozov,Yongchao Ge,Ninette Cohen,Lisa Edelmann,Betty Chang,Avinash Waghray,Jie Su,Sherly Pardo,Klaske D. Lichtenbelt,Marco Tartaglia,Bruce D. Gelb,Ihor R. Lemischka +20 more
TL;DR: In vitro-derived cardiomyocytes from LEOPARD syndrome iPSCs are larger, have a higher degree of sarcomeric organization and preferential localization of NFATC4 in the nucleus when compared with cardiomeocytes derived from human embryonic stem cells or wild-type iPSC derived from a healthy brother of one of the LEopARD syndrome patients, which correlate with a potential hypertrophic state.
Journal ArticleDOI
Hallucinogens Recruit Specific Cortical 5-HT2A Receptor-Mediated Signaling Pathways to Affect Behavior
Javier González-Maeso,Noelia V. Weisstaub,Mingming Zhou,Pokman Chan,Lidija Ivic,Rosalind L. Ang,Alena Lira,Maria Bradley-Moore,Yongchao Ge,Qiang Zhou,Stuart C. Sealfon,Jay A. Gingrich +11 more
TL;DR: By genetically expressing 2AR only in cortex, it is shown that 2AR-regulated pathways on cortical neurons are sufficient to mediate the signaling pattern and behavioral response to hallucinogens.
Journal ArticleDOI
Wdr5 Mediates Self-Renewal and Reprogramming via the Embryonic Stem Cell Core Transcriptional Network
Yen-Sin Ang,Su-Yi Tsai,Dung Fang Lee,Jonathan M. Monk,Jie Su,Kajan Ratnakumar,Junjun Ding,Yongchao Ge,Henia Darr,Betty Chang,Jianlong Wang,Michael Rendl,Emily Bernstein,Christoph Schaniel,Ihor R. Lemischka +14 more
TL;DR: It is shown that WD repeat domain 5 (Wdr5), a core member of the mammalian Trithorax (trxG) complex, positively correlates with the undifferentiated state and is a regulator of ES cell self-renewal.
Journal ArticleDOI
Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise.
James A. Sanford,Christopher D. Nogiec,Malene E. Lindholm,Joshua N. Adkins,David Amar,Surendra Dasari,Jonelle K. Drugan,Facundo M. Fernández,Shlomit Radom-Aizik,Simon Schenk,Michael Snyder,Russell P. Tracy,Patrick M. Vanderboom,Scott Trappe,Martin J. Walsh,Charles R. Evans,Yafeng Li,Lyl Tomlinson,D. Lee Alekel,Iddil Bekirov,Amanda T. Boyce,Josephine Boyington,Jerome L. Fleg,Lyndon Joseph,Maren R. Laughlin,Padma Maruvada,Stephanie A. Morris,Joan McGowan,Concepcion R. Nierras,Vinay Pai,Charlotte A. Peterson,Ed Ramos,Mary Roary,John P. Williams,Ashley Xia,Elaine Cornell,Jessica Rooney,Michael Miller,Walter T. Ambrosius,Scott Rushing,Cynthia L. Stowe,W. Jack Rejeski,Barbara J. Nicklas,Marco Pahor,Ching-ju Lu,Todd A. Trappe,Toby Chambers,Ulrika Raue,Bridget Lester,Bryan C. Bergman,David H. Bessesen,Catherine M. Jankowski,Wendy M. Kohrt,Edward L. Melanson,Kerrie L. Moreau,Irene E. Schauer,Robert S. Schwartz,William E. Kraus,Cris A. Slentz,Kim M. Huffman,Johanna L. Johnson,Leslie H. Willis,L S. Kelly,Joseph A. Houmard,Gabriel S. Dubis,Nick Broskey,Bret H. Goodpaster,Lauren M. Sparks,Paul M. Coen,Dan M. Cooper,Fadia Haddad,Tuomo Rankinen,Eric Ravussin,Neil M. Johannsen,Melissa Harris,John M. Jakicic,Anne B. Newman,Daniel Forman,Erin E. Kershaw,Renee J. Rogers,Bradley C. Nindl,Lindsay C. Page,Maja Stefanovic-Racic,Susan Barr,Blake B. Rasmussen,Tatiana Moro,Doug Paddon-Jones,Elena Volpi,Heidi Spratt,Nicolas Musi,Sara E. Espinoza,Darpan I. Patel,Monica C. Serra,Jonathan Gelfond,Aisling Burns,Marcas M. Bamman,Thomas W. Buford,Gary Cutter,Sue C. Bodine,Karyn A. Esser,Rodger P. Farrar,Laurie J. Goodyear,Michael F. Hirshman,Brent G. Albertson,Wei-Jun Qian,Paul D. Piehowski,Marina A. Gritsenko,Matthew E. Monore,Vladislav A. Petyuk,Jason E. McDermott,Joshua N. Hansen,Chelsea Hutchison,Samuel G. Moore,David A. Gaul,Clary B. Clish,Julian Avila-Pacheco,Courtney Dennis,Manolis Kellis,Steve Carr,Pierre M. Jean-Beltran,Hasmik Keshishian,D. R. Mani,Karl R. Clauser,Karsten Krug,Charlie Mundorff,Cadence Pearce,Anna A. Ivanova,Eric A. Ortlund,Kristal M. Maner-Smith,Karan Uppal,Tiantian Zhang,Stuart C. Sealfon,Elena Zaslavsky,Venugopalan D. Nair,SiDe Li,Nimisha Jain,Yongchao Ge,Yifei Sun,German Nudelman,Frederique Ruf-Zamojski,Gregory R. Smith,Nhanna Pincas,Aliza B. Rubenstein,Mary Anne S. Amper,Nitish Seenarine,Tuuli Lappalainen,Ian R. Lanza,K. Sreekumaran Nair,Katherine Klaus,Stephen B. Montgomery,Kevin S. Smith,Bingqing Zhao,Chia-Jiu Hung,Navid Zebarjadi,Brunilda Balliu,Laure Fresard,Charles F. Burant,Jun Li,Maureen Kachman,Tanu Soni,Alexander B. Raskind,Robert E. Gerszten,Jeremy M. Robbins,Olga Ilkayeva,Michael J. Muehlbauer,Christopher B. Newgard,Euan A. Ashley,Matthew T. Wheeler,David Jimenez-Morales,Archana Raja,Karen P. Dalton,Jimmy Zhen,Young Suk Kim,Jeffrey W. Christle,Shruti Marwaha,Elizabeth T Chin,Steven G. Hershman,Trevor Hastie,Robert Tibshirani,Manuel A. Rivas +179 more
TL;DR: The Molecular Transducers of Physical Activity Consortium (MoTrPAC) will provide a public database that is expected to enhance the understanding of the health benefits of exercise and to provide insight into how physical activity mitigates disease.