O
Omolola Eniola-Adefeso
Researcher at University of Michigan
Publications - 61
Citations - 2067
Omolola Eniola-Adefeso is an academic researcher from University of Michigan. The author has contributed to research in topics: Medicine & Adhesion. The author has an hindex of 22, co-authored 52 publications receiving 1596 citations.
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Journal ArticleDOI
Extracellular vesicles as drug delivery systems: lessons from the liposome field.
Roy van der Meel,Marcel H.A.M. Fens,Pieter Vader,Wouter W. van Solinge,Omolola Eniola-Adefeso,Raymond M. Schiffelers +5 more
TL;DR: By applying beneficial features of EVs to liposomes and vice versa, improved drug carriers can be developed which will advance the field of nanomedicines and ultimately improve patient outcomes.
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Potential role of size and hemodynamics in the efficacy of vascular-targeted spherical drug carriers
TL;DR: Overall, the presented data suggests that spheres 2-5 microm in size are optimal for targeting the wall in medium to large vessels relevant in several cardiovascular diseases.
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Margination propensity of vascular-targeted spheres from blood flow in a microfluidic model of human microvessels
TL;DR: This work represents the first evidence that nanospheres may not exhibit "near wall excess" in microvessels, e.g., arterioles and venules, and therefore may not be suitable for imaging and drug delivery applications in cancer and other diseases affecting microvessel.
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The margination propensity of ellipsoidal micro/nanoparticles to the endothelium in human blood flow
TL;DR: Interestingly, rod-shaped microparticles with high aspect ratios display significantly improved margination compared to spheres of equal volume, particularly under high shear rates and disturbed flow profiles, which suggests that nanorod display minimal margination due to their inability to effectively localize to the vessel wall in the presence of RBCs.
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Targeting therapeutics to the vascular wall in atherosclerosis--carrier size matters.
Phapanin Charoenphol,Supriya Mocherla,Diane Bouis,Katawut Namdee,David J. Pinsky,Omolola Eniola-Adefeso +5 more
TL;DR: Overall, the presented results suggest that micron-sized spherical particles (2 μm), not nanospheres, are optimal for vascular-targeted drug delivery applications in medium to large vessel relevant in atherosclerosis.