M
Marcella Franquesa
Researcher at Group Health Cooperative
Publications - 75
Citations - 3523
Marcella Franquesa is an academic researcher from Group Health Cooperative. The author has contributed to research in topics: Mesenchymal stem cell & Transplantation. The author has an hindex of 32, co-authored 72 publications receiving 2873 citations. Previous affiliations of Marcella Franquesa include Erasmus University Medical Center & Bellvitge University Hospital.
Papers
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Journal ArticleDOI
Size-Exclusion Chromatography-based isolation minimally alters Extracellular Vesicles' characteristics compared to precipitating agents.
Ana Gámez-Valero,Ana Gámez-Valero,Marta Monguió-Tortajada,Laura Carreras-Planella,Marcella Franquesa,Katrin Beyer,Francesc E. Borràs +6 more
TL;DR: PEG and PROSPR-based EV isolation resulted in reduced cell viability in vitro and it is stressed that appropriate EV-isolation method should be considered depending on the forthcoming application of the purified EVs.
Journal ArticleDOI
Mammalian Target of Rapamycin Pathway Blockade Slows Progression of Diabetic Kidney Disease in Rats
Nuria Lloberas,Josep M. Cruzado,Marcella Franquesa,Immaculada Herrero-Fresneda,Joan Torras,Gabriela Alperovich,Inés Rama,August Vidal,Josep M. Grinyó +8 more
TL;DR: It is interesting that D+SRL was associated with a significant reduction of renal TGF-beta1 and glomerular connective tissue growth factor and reduced significantly the mesangial matrix accumulation that is characteristic of diabetic nephropathy.
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Mesenchymal Stem Cell-Derived Interleukin 1 Receptor Antagonist Promotes Macrophage Polarization and Inhibits B Cell Differentiation
Patricia Luz-Crawford,Farida Djouad,Farida Djouad,Karine Toupet,Karine Toupet,Claire Bony,Claire Bony,Marcella Franquesa,Martin J. Hoogduijn,Christian Jorgensen,Christian Jorgensen,Danièle Noël,Danièle Noël +12 more
TL;DR: In this article, the role of interleukin 1 receptor antagonist (IL1RA) in mediating the immunosuppressive effect of mesenchymal stem/stromal cells (MSCs) has been investigated.
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Human adipose tissue-derived mesenchymal stem cells abrogate plasmablast formation and induce regulatory B cells independently of T helper cells.
Marcella Franquesa,F. Mensah,Ruth Huizinga,Tanja Strini,Louis Boon,Eleuterio Lombardo,Olga DelaRosa,Jon D. Laman,Josep M. Grinyó,Willem Weimar,Michiel G. H. Betjes,Carla C. Baan,Martin J. Hoogduijn +12 more
TL;DR: It is demonstrated that ASC affect B cell biology in vitro, suggesting that they can be a tool for the modulation of the B‐cell response in immune disease.
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Immunomodulatory effect of mesenchymal stem cells on B cells.
TL;DR: The research on T cell immunosuppression therapies and Mesenchymal stem cells are arising as a potent therapeutic tool in transplantation due to their regenerative and immunomodulatory properties, and although data regarding the modulatory effects of MSCs on alloantigen-specific humoral response in humans is scarce, it has been demonstrated that M SCs significantly affect B cell functioning.