M
Marcus Karlstetter
Researcher at University of Cologne
Publications - 37
Citations - 2057
Marcus Karlstetter is an academic researcher from University of Cologne. The author has contributed to research in topics: Microglia & Retinal degeneration. The author has an hindex of 20, co-authored 37 publications receiving 1709 citations. Previous affiliations of Marcus Karlstetter include Bayer HealthCare Pharmaceuticals & University of Regensburg.
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Journal ArticleDOI
Retinal microglia: Just bystander or target for therapy?
TL;DR: It is concluded that this resident immune cell of the retina cannot be simply regarded as bystander of disease but may instead be a potential therapeutic target to be modulated in the treatment of degenerative and inflammatory diseases ofThe retina.
Journal ArticleDOI
CRX ChIP-seq reveals the cis-regulatory architecture of mouse photoreceptors
Joseph C. Corbo,Karen A. Lawrence,Marcus Karlstetter,Connie A. Myers,Musa Abdelaziz,William Dirkes,Karin Weigelt,Martin Seifert,Vladimir Benes,Lars G. Fritsche,Bernhard H. F. Weber,Thomas Langmann +11 more
TL;DR: CRX combinatorially orchestrates the transcriptional networks of both rods and cones by coordinating the expression of photoreceptor genes including most retinal disease genes, and pinpoints thousands of noncoding regions of relevance to both Mendelian and complex Retinal disease.
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Microglia in the healthy and degenerating retina: Insights from novel mouse models
TL;DR: An overview of microglial homeostasis in the healthy and degenerating retina is provided and microglia-targeted therapies are envisioned which could delay or attenuate degenerative retinal disease.
Journal ArticleDOI
Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis
Marcus Karlstetter,Caroline Nothdurfter,Alexander Aslanidis,Katharina Moeller,Felicitas Horn,Rebecca Scholz,Harald Neumann,Bernhard H. F. Weber,Rainer Rupprecht,Thomas Langmann +9 more
TL;DR: TSPO was strongly up-regulated in microglial cells of the dystrophic mouse retina and also co-localized with microglia in human retinas, suggesting that TSPO is highly expressed in reactive retinalmicroglia and a promising target to control microglian reactivity during retinal degeneration.
Journal ArticleDOI
Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype
Konstantin Dirscherl,Marcus Karlstetter,Stefanie Ebert,Dominik Kraus,Julia Hlawatsch,Yana Walczak,Christoph Moehle,Rudolf Fuchshofer,Thomas Langmann +8 more
TL;DR: The findings confirm the inhibitory effects of luteolin on pro-inflammatory cytokine expression in microglia and suggest that this flavonoid is a potent modulator of microglial activation and affects several signaling pathways leading to a unique phenotype with anti-inflammatory, anti-oxidative, and neuroprotective characteristics.