M
Marek Ancukiewicz
Researcher at Harvard University
Publications - 143
Citations - 20032
Marek Ancukiewicz is an academic researcher from Harvard University. The author has contributed to research in topics: Radiation therapy & Bevacizumab. The author has an hindex of 56, co-authored 142 publications receiving 18390 citations. Previous affiliations of Marek Ancukiewicz include University of Colorado Denver & Veterans Health Administration.
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Journal ArticleDOI
Higher versus Lower Positive End-Expiratory Pressures in Patients with the Acute Respiratory Distress Syndrome
Roy G. Brower,Paul N. Lanken,Neil R. MacIntyre,Michael A. Matthay,Alan H. Morris,Marek Ancukiewicz,David A. Schoenfeld,B. Taylor Thompson +7 more
TL;DR: In patients with acute lung injury and ARDS who receive mechanical ventilation with a tidal-volume goal of 6 ml per kilogram of predicted body weight and an end-inspiratory plateau-pressure limit of 30 cm of water, clinical outcomes are similar whether lower or higher PEEP levels are used.
Journal ArticleDOI
AZD2171, a Pan-VEGF Receptor Tyrosine Kinase Inhibitor, Normalizes Tumor Vasculature and Alleviates Edema in Glioblastoma Patients
Tracy T. Batchelor,A. Gregory Sorensen,A. Gregory Sorensen,Emmanuelle di Tomaso,Wei Ting Zhang,Wei Ting Zhang,Dan G. Duda,Kenneth S. Cohen,Kevin R. Kozak,Daniel P. Cahill,Poe Jou Chen,Poe Jou Chen,Mingwang Zhu,Mingwang Zhu,Marek Ancukiewicz,Maciej M. Mrugala,Scott R. Plotkin,Jan Drappatz,David N. Louis,Percy Ivy,David T. Scadden,Thomas Benner,Jay S. Loeffler,Patrick Y. Wen,Rakesh K. Jain +24 more
TL;DR: This study provides insight into different mechanisms of action of this class of drugs in recurrent glioblastoma patients and suggests that the timing of combination therapy may be critical for optimizing activity against this tumor.
Journal ArticleDOI
Relative biological effectiveness (RBE) values for proton beam therapy.
Harald Paganetti,Andrzej Niemierko,Marek Ancukiewicz,Leo E. Gerweck,Michael Goitein,Jay S. Loeffler,Herman D. Suit +6 more
TL;DR: There is too much uncertainty in the RBE value for any human tissue to propose RBE values specific for tissue, dose/fraction, proton energy, etc, and experimental in vivo and clinical data indicate that continued employment of a generic RBEvalue is reasonable.
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Efficacy and Safety of Corticosteroids for Persistent Acute Respiratory Distress Syndrome
Kenneth P. Steinberg,Leonard D. Hudson,Richard B. Goodman,Catherine L. Hough,Paul N. Lanken,Robert C. Hyzy,B. Taylor Thompson,Marek Ancukiewicz +7 more
TL;DR: A multicenter, randomized controlled trial of corticosteroids in patients with persistent acute respiratory distress syndrome found that methylprednisolone improved survival and biochemical markers of inflammation and fibroproliferation, and infectious complications.
Journal ArticleDOI
Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy
Yuhui Huang,Jianping Yuan,Elda Righi,Walid S. Kamoun,Marek Ancukiewicz,Jean Nezivar,Michael Santosuosso,John D. Martin,Margaret R. Martin,Fabrizio Vianello,Pierre Leblanc,Lance L. Munn,Peigen Huang,Dan G. Duda,Dai Fukumura,Rakesh K. Jain,Mark C. Poznansky +16 more
TL;DR: It is demonstrated that targeting tumor vasculature with lower vascular-normalizing doses, but not high antivascular/antiangiogenic doses, of an anti-VEGF receptor 2 (VEGFR2) antibody results in a more homogeneous distribution of functional tumor vessels.