M
Mark C. Poznansky
Researcher at Harvard University
Publications - 167
Citations - 8881
Mark C. Poznansky is an academic researcher from Harvard University. The author has contributed to research in topics: Immune system & Cancer. The author has an hindex of 40, co-authored 153 publications receiving 6151 citations. Previous affiliations of Mark C. Poznansky include Stony Brook University & St Mary's Hospital.
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Journal ArticleDOI
Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity.
Wilfredo F. Garcia-Beltran,Wilfredo F. Garcia-Beltran,Evan C. Lam,Kerri St. Denis,Adam Nitido,Zeidy H. Garcia,Blake M. Hauser,Jared Feldman,Maia N. Pavlovic,David Gregory,Mark C. Poznansky,Alex Sigal,Alex Sigal,Aaron G. Schmidt,A. John Iafrate,Vivek Naranbhai,Vivek Naranbhai,Alejandro B. Balazs +17 more
TL;DR: In this article, the authors evaluated the neutralization potency of 99 individuals that received one or two doses of either BNT162b2 or mRNA-1273 vaccines against pseudoviruses representing 10 globally circulating strains of SARS-CoV-2.
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mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant
Wilfredo F. Garcia-Beltran,K. S. St. Denis,Angelique Hoelzemer,Evan C. Lam,Adam Nitido,M. Sheehan,Cristhian Berríos,Onosereme Ofoman,Christina C. Chang,Blake M. Hauser,Jared Feldman,Alex Roederer,David Gregory,Mark C. Poznansky,Aaron G. Schmidt,A. John Iafrate,Vivek Naranbhai,Alejandro B. Balazs +17 more
TL;DR: In this article , the authors measured the neutralization potency of sera from 88 mRNA-1273, 111 BNT162b, and 40 Ad26.1.1/B.COV2.
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Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy
Yuhui Huang,Jianping Yuan,Elda Righi,Walid S. Kamoun,Marek Ancukiewicz,Jean Nezivar,Michael Santosuosso,John D. Martin,Margaret R. Martin,Fabrizio Vianello,Pierre Leblanc,Lance L. Munn,Peigen Huang,Dan G. Duda,Dai Fukumura,Rakesh K. Jain,Mark C. Poznansky +16 more
TL;DR: It is demonstrated that targeting tumor vasculature with lower vascular-normalizing doses, but not high antivascular/antiangiogenic doses, of an anti-VEGF receptor 2 (VEGFR2) antibody results in a more homogeneous distribution of functional tumor vessels.
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Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor
Gregor B. Adams,Karissa T. Chabner,Ian R. Alley,Douglas P. Olson,Zbigniew M. Szczepiorkowski,Zbigniew M. Szczepiorkowski,Mark C. Poznansky,Claudine H. Kos,Martin R. Pollak,Edward M. Brown,David T. Scadden +10 more
TL;DR: It is shown that, through the CaR, the simple ionic mineral content of the niche may dictate the preferential localization of adult mammalian haematopoiesis in bone.
Journal ArticleDOI
Active movement of T cells away from a chemokine.
Mark C. Poznansky,Ivona T. Olszak,Russell B. Foxall,Richard H. Evans,Andrew D. Luster,David T. Scadden +5 more
TL;DR: The phenomenon of movement away from a chemokine represents a previously unknown mechanism regulating the localization of mature T cells and adds to the functional repertoire of chemokines that may participate in immune physiology and may be applied therapeutically to alter the immune response.