M
Marek Malik
Researcher at National Institutes of Health
Publications - 548
Citations - 63023
Marek Malik is an academic researcher from National Institutes of Health. The author has contributed to research in topics: QT interval & Myocardial infarction. The author has an hindex of 78, co-authored 535 publications receiving 58778 citations. Previous affiliations of Marek Malik include St. George's University & Imperial College London.
Papers
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Journal ArticleDOI
Nitroglycerin induced syncope occurs in subjects with delayed phase shift of baroreflex action.
Vojtech Melenovsky,Dan Wichterle,Jan Malik,Jan Simek,Jaromír Hradec,Richard Ceska,Marek Malik +6 more
TL;DR: Subjects with prolonged PCR are prone to NTG induced syncope because of increased lagging and, consequently, less stable baroreflex control.
Journal ArticleDOI
Baseline correction in parallel thorough QT studies.
TL;DR: Because of possible inaccuracy introduced by time-averaged baseline correction, the time-matched baseline correction appears to be preferable for a parallel TQT study to both reduce the intrinsic variability due to circadian patterns and obtain more accurate point estimates.
Journal ArticleDOI
Computer simulation of electronic interactions during excitation and repolarisation of myocardial tissue.
Marek Malik,A. J. Camm +1 more
TL;DR: The paper presents three series of experiments examining the dependence of the accuracy of the model on the size of the modelled tissue, changes of the shape of simulated T-waves due to electrotonic interactions and arrhythmogenic processes caused by lowering the threshold of the electric flow which excites individual cells.
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Cross-spectral analysis of heart rate and blood pressure modulations.
TL;DR: The study concludes that the appropriate, and not always easy, selection of the frequency of maximum coherence between BP and HR oscillation is crucial for an accurate cross‐spectral assessment of baroreflex sensitivity.
Journal ArticleDOI
QRS micro-fragmentation as a mortality predictor
Katerina Hnatkova,Irena Andršová,Tomáš Novotný,Annie Britton,Martin J. Shipley,Bert Vandenberk,David J. Sprenkeler,M. Juhani Junttila,Tobias Reichlin,Simon Schlögl,Marc A. Vos,Tim Friede,Axel Bauer,Heikki V. Huikuri,Rik Willems,Georg Schmidt,Michael R. Franz,Christian Sticherling,Markus Zabel,Marek Malik +19 more
TL;DR: Electrophysiologic abnormalities that contribute to increased QRS-μf values are likely responsible for the predictive power of visibleQRS-Mf, and QRS ‘micro’-fragmentation was a powerful mortality risk factor independent of several previously established risk indices.