M
Margaret C. Bash
Researcher at Center for Biologics Evaluation and Research
Publications - 30
Citations - 766
Margaret C. Bash is an academic researcher from Center for Biologics Evaluation and Research. The author has contributed to research in topics: Neisseria meningitidis & Neisseria gonorrhoeae. The author has an hindex of 14, co-authored 30 publications receiving 718 citations. Previous affiliations of Margaret C. Bash include Uniformed Services University of the Health Sciences.
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Journal ArticleDOI
Effect of O Acetylation of Neisseria meningitidis Serogroup A Capsular Polysaccharide on Development of Functional Immune Responses
David S. Berry,David S. Berry,Freyja Lynn,Che-Hung Lee,Carl E. Frasch,Margaret C. Bash,Margaret C. Bash +6 more
TL;DR: The dramatic reduction in immunogenicity associated with removal of O-acetyl groups indicates that O acetylation is essential to the immunogenic epitopes of serogroup A PS.
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Vaccines against Gonorrhea: Current status and Future Challenges
TL;DR: Mechanisms by which Neisseria gonorrhoeae avoids inducing a protective adaptive response are being elucidated using human cells and the mouse model, which suggests Th1-inducing adjuvants may be key in vaccine-induced protection.
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Impact of Fluoroquinolone Resistance Mutations on Gonococcal Fitness and In Vivo Selection for Compensatory Mutations
Anjali N. Kunz,Afrin A. Begum,Hong Wu,Jonathan A. D'Ambrozio,James M. Robinson,William M. Shafer,William M. Shafer,Margaret C. Bash,Ann E. Jerse +8 more
TL;DR: GyrA(91/95) mutations may contribute to the spread of QRNG and further acquisition of a parC86 mutation abrogates this fitness advantage; however, compensatory mutations can occur that restore in vivo fitness and maintain Cip(R).
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Genetic diversity of three lgt loci for biosynthesis of lipooligosaccharide (LOS) in Neisseria species.
TL;DR: The data demonstrated that pathogenic and commensal NeISSeria share a common lgt gene pool and horizontal gene transfer appears to contribute to the genetic diversity of the lgt loci in Neisseria.
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Analysis of Neisseria meningitidis class 3 outer membrane protein gene variable regions and type identification using genetic techniques.
TL;DR: In this paper, the relationship between serotype and variable region (VR) genotype was evaluated by using molecular techniques, and a limited number of unique sequences at each of four VRs (VR1 to VR4) were found.