Carl E. Frasch

TL;DR: A sensitive silver stain for detecting bacterial lipopolysaccharides in polyacrylamide gels is developed by modifying the silver-staining method used for proteins, which is 500 times more sensitive than the periodic acid-Schiff stain and can detect less than 5 ng of rough type lipopolySaccharides.

TL;DR: A new serotyping nomenclature and scheme based on these two proteins and the lipopolysaccharide are proposed, which are predominant proteins, show a useful degree of antigenic variation, and are epidemiologically relevant.

TL;DR: Combination immunotherapy consisting of a single early post-transplant infusion of in vivo vaccine-primed and ex vivo costimulated autologous T cells followed by post-Transplant booster immunizations improved the severe immunodeficiency associated with high-dose chemotherapy and led to the induction of clinically relevant immunity in adults within a month after transplantation.

TL;DR: Streptococcus pneumoniae is a major human pathogen causing pneumonia, sepsis, meningitis, and otitis media, and elderly adults because their immune systems are either unprepared or unable to respond effectively to it.

TL;DR: The specified assay, which includes the critical parameters of target strain, incubation time, and complement source, will facilitate interlaboratory comparisons of the functional antibody produced in response to current or developing serogroup A and C meningococcal vaccines.