M
Margaret Duffy
Researcher at University College Dublin
Publications - 14
Citations - 646
Margaret Duffy is an academic researcher from University College Dublin. The author has contributed to research in topics: Hepatitis C virus & Viral load. The author has an hindex of 9, co-authored 14 publications receiving 628 citations.
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Journal ArticleDOI
CD4 T Helper Type 1 and Regulatory T Cells Induced against the Same Epitopes on the Core Protein in Hepatitis C Virus- Infected Persons
Angus Macdonald,Margaret Duffy,Miriam T. Brady,Susan McKiernan,William W. Hall,John Hegarty,Michael P. Curry,Kingston H. G. Mills +7 more
TL;DR: It is demonstrated that T helper type 1 and regulatory T cells are induced against the same epitopes on the core protein during HCV infection.
Journal ArticleDOI
Dating the common ancestor of SIVcpz and HIV-1 group M and the origin of HIV-1 subtypes by using a new method to uncover clock-like molecular evolution
Marco Salemi,Korbinian Strimmer,William W. Hall,Margaret Duffy,Eric Delaporte,Souleymane Mboup,Martine Peeters,Anne-Mieke Vandamme +7 more
TL;DR: A new method of molecular clock analysis, called Site Stripping for Clock Detection (SSCD), which allows selection of nucleotide sites evolving at an equal rate in different lineages, and is able to date exactly the ‘known’ origin of the infection of HIV‐1 group M.
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Expansion of innate CD5pos B cells expressing high levels of CD81 in hepatitis C virus infected liver.
Michael P. Curry,Lucy Golden-Mason,Derek G. Doherty,Tina Deignan,Suzanne Norris,Margaret Duffy,Niamh Nolan,William W. Hall,John Hegarty,Cliona O'Farrelly +9 more
TL;DR: Increased expression of CD81 on innate B cells, a population that is expanded in the livers and peripheral blood of chronic HCV-infected patients, suggests a role in viral specific activation and clonal proliferation in chronicHCV infection.
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Rapid molecular detection of the H275Y oseltamivir resistance gene mutation in circulating influenza A (H1N1) viruses.
TL;DR: A one-step allelic discrimination assay which rapidly (2h) detects this resistance mutation and is capable of detecting the antiviral resistance mutation in a mixture of wild type H275 and mutant H275Y targets.
Journal ArticleDOI
High morbidity and mortality associated with an outbreak of influenza A(H3N2) in a psycho-geriatric facility
G. Sayers,Derval Igoe,Michael J. Carr,M. Cosgrave,Margaret Duffy,Brendan Crowley,B. O'herlihy +6 more
TL;DR: Control measures included oseltamivir treatment for cases and prophylaxis for contacts, standard and droplet infection control precautions, active surveillance for early detection and isolation of potential cases, and vaccination of residents and staff of such facilities remains the key influenza prevention strategy.