M
Margaret J. Polley
Researcher at Scripps Health
Publications - 13
Citations - 1363
Margaret J. Polley is an academic researcher from Scripps Health. The author has contributed to research in topics: Platelet activation & Molecular mass. The author has an hindex of 10, co-authored 13 publications receiving 1342 citations.
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Journal ArticleDOI
Human Monocytes: Distinct Receptor Sites for the Third Component of Complement and for Immunoglobulin G
Heinz Huber,Margaret J. Polley,William D. Linscott,H. Hugh Fudenberg,Hans J. Müller-Eberhard +4 more
TL;DR: The two monocyte receptors exert a cooperative effect on ingestion by monocytes of erythrocytes coated with γG antibody in the presence of inhibitory amounts of free γE, which is independent of complement.
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Formation and functional significance of a molecular complex derived from the second and the fourth component of human complement.
TL;DR: It was shown that the cell-bound form of C'3 convertase is cytolytically active and that the free enzyme is able to induce lysis from the fluid phase of erythrocytes from patients with paroxysmal nocturnal hemoglobinuria.
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Human platelet activation by C3a and C3a des-arg
TL;DR: The data suggest the possibility of a C3a (C3a des-arg) receptor on human platelets and synergism with ADP of equal significance in both aggregation and the release reaction.
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Enhancement of the hemolytic activity of the second component of human complement by oxidation
TL;DR: Evidence has been presented in support of the hypothesis that the modification resulting from treatment of C'2 with a critical concentration of iodine consists of oxidation of one or more sulfhydryl group within the molecule.
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The second component of human complement: its isolation, fragmentation by C'1 esterase, and incorporation into C'3 convertase.
TL;DR: Immunochemical analysis using a variety of specific antisera, including a monospecific antiserum to the isolated protein, indicate that the C'2 protein represents a heretofore unrecognized human serum constituent.