M
Mari Pekkanen-Mattila
Researcher at University of Tampere
Publications - 37
Citations - 1582
Mari Pekkanen-Mattila is an academic researcher from University of Tampere. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 16, co-authored 32 publications receiving 1394 citations. Previous affiliations of Mari Pekkanen-Mattila include Karolinska Institutet.
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Journal ArticleDOI
Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture.
Anna L. Lahti,Ville J. Kujala,Hugh Chapman,A. Koivisto,Mari Pekkanen-Mattila,Erja Kerkelä,Jari Hyttinen,Jari Hyttinen,Kimmo Kontula,Heikki Swan,Bruce R. Conklin,Shinya Yamanaka,Shinya Yamanaka,Olli Silvennoinen,Katriina Aalto-Setälä +14 more
TL;DR: The iPSC-derived, disease-specific cardiomyocytes derived from an individual with LQT2 carrying the R176W mutation in the KCNH2 (HERG) gene could serve as an important platform to study pathophysiological mechanisms and drug sensitivity in L QT2.
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A Defined and Xeno-Free Culture Method Enabling the Establishment of Clinical-Grade Human Embryonic, Induced Pluripotent and Adipose Stem Cells
Kristiina Rajala,Bettina Lindroos,Samer M.I. Hussein,Riikka S. Lappalainen,Mari Pekkanen-Mattila,José Inzunza,Björn Rozell,Susanna Miettinen,Susanna Narkilahti,Erja Kerkelä,Katriina Aalto-Setälä,Timo Otonkoski,Riitta Suuronen,Riitta Suuronen,Outi Hovatta,Heli Skottman +15 more
TL;DR: The results demonstrate that human ESCs, iPSCs and ASCs can be maintained in the same defined xeno-free medium formulation for a prolonged period of time while maintaining their characteristics, demonstrating the applicability of the simplified xenos-freeMedium formulation for the production of clinical-grade stem cells.
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A 3D Alzheimer's disease culture model and the induction of P21-activated kinase mediated sensing in iPSC derived neurons
Dawei Zhang,Mari Pekkanen-Mattila,Mansoureh Shahsavani,Anna Falk,Ana I. Teixeira,Anna Herland +5 more
TL;DR: It is proposed that the 3D in vitro model has higher resemblance to the AD pathology than conventional 2D cultures and could be used in further studies of the disease.
Journal ArticleDOI
Cell model of catecholaminergic polymorphic ventricular tachycardia reveals early and delayed afterdepolarizations.
Kirsi Kujala,Jere Paavola,Jere Paavola,Anna L. Lahti,Kim Larsson,Mari Pekkanen-Mattila,Matti Viitasalo,Annukka M. Lahtinen,Lauri Toivonen,Kimmo Kontula,Heikki Swan,Mika Laine,Mika Laine,Olli Silvennoinen,Katriina Aalto-Setälä +14 more
TL;DR: This cell model for CPVT provides a platform to study basic pathology, to screen drugs, and to optimize drug therapy and shows aberrant Ca2+ cycling characteristic of CPVT and in addition to DADs it displays EADs.
Journal ArticleDOI
Cardiac Differentiation of Pluripotent Stem Cells
TL;DR: The strategies for the generation of cardiomyocytes from pluripotent stem cells and their characteristics are discussed, as well as some applications for the cells are highlighted.